非胰岛素依赖型糖尿病危险因素的病例对照研究  

EPIDEMIOLOGICAL STUDY OF DIABETES MELLITUS IN SHANDONG PROVINCE Ⅱ.CASECONTROL STUDY ON THE RISK FACTORS OF NONINSULINDEPENDENT DIABETES MELLITUS

作　　者：赵仲堂[1,2,3,4,5,6,7,8] 王明连 郝凤荣 潘玉珍[1,2,3,4,5,6,7,8] 徐晓菲 于洪霞[1,2,3,4,5,6,7,8] 冯月秋 王景常[1,2,3,4,5,6,7,8] 张成美 顾吉达[1,2,3,4,5,6,7,8] 李光荣 杨汉银 马德伟 姜宝法 张宝珠 

机构地区：[1]山东医科大学公共卫生学院 [2]济南军区军事医学研究所 [3]枣庄矿务局东郊医院 [4]枣庄市卫生防疫站 [5]烟台长岛县医院砣矶分院 [6]滨州医学院 [7]济南长清县医院 [8]山东医科大学附属

出　　处：《山东医科大学学报》1998年第1期44-48,共5页Acta Academiae Medicinae Shandong

摘　　要：为了解ＮＩＤＤＭ的危险因素，为该病适宜的社区干预对策与措施的制订提供依据，对２２２例患者进行了１：２配比病例对照研究。结果在５０个分析变量中，最终进入多因素Ｌｏｇｉｓｔｉｃ回归模型有意义的因素有家族遗传系数、体重指数、喜素食和收缩压，相对危险度估计值（ＯＲ）分别为３．０７、２．１０、０．３７、１．５２。交互作用分析表明，当阳性家族史与超重或不良饮食习惯二者并存时，ＯＲ值表现为加法模型协同作用；当阳性家族史、超重、不良饮食习惯三者并存时，ＯＲ值表现为乘法模型协同作用。由此可见，除阳性家族史、超重者为ＮＩＤＤＭ的高危人群外，阳性家族史与超重或不良饮食习惯并存者，特别是三者并存，为该病社区干预的重点人群。To understand the risk factors of noninsulindependant diabetes mellitus(NIDDM) so as to formulate and implement the intervention program of the disease,a 1:2 matched casecontrol study of 222 cases was conducted.Of the 50 variables analysed,family diabetes mellitus(DM)heredity index,body mass index(BMI),favour of vegetarian diet and systolic blood pressure were significantly correlated to NIDDM in the model of multifactorial logistic regression,and the OR values are 3.07,2.10,0.37 and 1.52 respectively.When family DM history,overweight(BMI≥24)or unhealthy diet habit coexist,OR value shows additive synergism;when the three factors of family DM history,overweight and unhealthy diet habit coexist,the OR value shows multiplicative synergism according to the interaction analysis.So the conclusion can be drawn that those who have family DM history and are overweight or keep unhealthy diet habit,especially when the three factors are present simultaneously,are the key population of the community intervention program of the disease.

关 键 词：IDDM 糖尿病 病例对照研究 危险因素 

分 类 号：R587.102[医药卫生—内分泌]