他克莫司药物浓度测定异常数据原因分析  

Analysis of Abnormal Data of Tacrolimus Concentration in blood

作　　者：方崇波[1] 

机构地区：[1]宁波市医疗中心李惠利医院,浙江宁波315040

出　　处：《中国现代应用药学》2009年第3期257-258,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的探究器官移植患者应用他克莫司治疗后异常血药浓度产生的原因。方法对本院1947例次血药浓度进行监测,并对检测结果进行分析。结果正常范围内有1296例次,占66.6%,低于下限的有382例次,占19.6%,高于上限的有269例次,占13.8%。结论多种原因引起血药浓度的变动,因此必须对检测结果提供合理解释,确保临床科学化个体给药,提高治疗水平。OBJECTIVE To study the reasons of abnormal tacrolimus concentration on organ transplant. METHODS Tacrolimus concentration in blood was determinated and date of concentration was analyzed according to clinical experience of American university of pittsburgh. RESULTS There were 1 296 cases（66.6% ） in normal range group,382 cases（ 19.6% ） below minimum group and 269 cases（ 13.8% ） over maximum group. CONCLUSION There are many reasons which can fluctuate drug. We must provided reasonable explanation on results, what can help individual adminstration.

关 键 词：他克莫司 血药浓度 器官移植 分析 

分 类 号：R969.11[医药卫生—药理学]