水朝阳旋覆花中新的细胞毒活性麝香草酚类化合物(英文)  

New Cytotoxic Thymol Derivatives from Inula helianthus-aquatica (Compositae)

作　　者：黄火强[1,2] 谭宁华[1] 曾广智[1] 嵇长久[1,2] 韩洪金[1] 徐俊驹[1,2] 张玉梅[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南昆明650204 [2]中国科学院研究生院,北京100049

出　　处：《云南植物研究》2009年第2期190-192,共3页Acta Botanica Yunnanica

基　　金：The National Natural Science Foundation of China (30725048);National Basic Research Program of China (2009CB522303);the Foundation of Chinese Academy of Sciences (West Light Program)

摘　　要：从水朝阳旋覆花(Inula helianthus-aquatica)的95 %乙醇提取物中分离得到4个麝香草酚类化合物,其中化合物1为新化合物。它们的化学结构通过波谱方法鉴定为: 8-hydroxy-9 ,10-dioxyisopropylidene-thymol(1) ,10-hydroxy-8 ,9-dioxyisopropylidene-thymol(2) ,8-hydroxy-9 ,10-diisobutyryloxy-thymol(3)和8 ,10-dihydroxy-9-isobutyryloxy-thymol(4)。肿瘤细胞毒试验结果表明它们在6种肿瘤细胞株上(K562,HT-29 , SGC-7901,DU145 , MDA-MB-231,U251)显示一定的细胞毒活性,其中化合物2活性最强,它的IC50值为4.20～33.12μmol/L。具有细胞毒活性的麝香草酚类化合物是首次在该种植物中发现。A new thymol derivative, 8-hydroxy-9, 10-dioxyisopropylidene-thymol （1）, together with three known thymol derivatives 10-hydroxy-8, 9-dioxyisopropylidene-thymol （2）, 8-hydroxy-9, 10-diisobutyryloxy-thymol （3） and 8, 10-dihydroxy-9-isobutyryloxy-thymol （4）, was isolated from 95% EtOH extract of the flowers of Inula helianthus-aquatica. Their structures were elucidated on the basis of detailed spectroscopic analysis. These compounds showed cytotoxicities on six cancer cell lines （K562, HT-29, SGC-7901, DU145, MDA-MB-231, U251）, and compound 2 is the strongest one with IC50s of 4.20-33.12umol/L. This is the first time that the cytotoxic thymol derivatives were isolated from this titled plant.

关 键 词：水朝阳旋覆花 麝香草酚类化合物 细胞毒活性 

分 类 号：R284[医药卫生—中药学]