持续性变应性鼻炎患者鼻中隔中神经肽的初步研究  

The investigation for the neuropeptides of nasal septum in perennial allergic rhinitis patient

作　　者：朱秋蓓[1] 张速勤[2] 吴静娴[2] 唐海红[2] 

机构地区：[1]上海第二军医大学长征医院耳鼻咽喉头颈外科,上海200003 [2]上海第二军医大学长海医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2009年第8期339-343,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨持续性变应性鼻炎患者鼻中隔软骨及骨性鼻中隔中的神经肽含量较正常个体有无变化,从而探讨鼻中隔矫正手术对于变应性鼻炎的治疗意义。方法:接受鼻中隔黏膜下切除术患者45例,其中持续性变应性鼻炎患者20例,单纯性鼻中隔偏曲患者25例。以放射免疫分析法测定手术切除的鼻中隔软骨及骨性鼻中隔中的神经肽SP、VIP及CGRP含量,并比较其差异。结果:正常组骨性鼻中隔中SP、VIP及CGRP含量较鼻中隔软骨高(P<0.05);鼻炎组鼻中隔软骨与骨性鼻中隔中SP、VIP含量无明显差异(P>0.05),鼻中隔软骨中CGRP含量较骨性鼻中隔高(P<0.05);鼻炎组鼻中隔软骨中SP、VIP含量较正常组高(P<0.05),CGRP含量无明显差异(P>0.05),骨性鼻中隔中SP、VIP及CGRP含量较正常组无明显差异(P>0.05)。结论:持续性变应性鼻炎患者鼻中隔中神经肽含量较正常个体增高,主要是鼻中隔软骨中的神经肽增高,因此鼻中隔黏骨膜下切除术后,变应性鼻炎能够得到缓解。Objective：To investigate the expression of neuropeptides in the nasal septum of the perennial aller gic rhinitis patients, and the mechanism of the alleviation effect of nasal septum rectification to allergic rhinitis. Method：Forty-five patients with deviation of nasal septum（20 with allergic rhinitis and 25 without）,who undergone nasal septum rectification in Changhai hospital during Jun to Dec,2007, were included in this research. The levels of SP, VIP, CGRP of the nasal septum were determined by radioimmunoassay. Result： In the normal controls, the SP,VIP and CGRP levels of the nasal septal cartilages were lower than that of the nasal septal bones （P〈0.05）, while in the perennial allergic rhinitis patients group, there were no statistical significance between the SP,VIP levels of the nasal septal cartilages and that of the nasal septal bones（P〉0.05）, and the CGRP level of the nasal septal cartilages was higher than that of the nasal septal bones（P〈0.05）. The SP , VIP levels of the nasal septal cartilages in the perennial allergic rhinitis patients group were higher than that in the normal controls （P〈0.05）, and there were no statistical significance between the levels of the nasal septal bones in the two groups （P〉0.05）. There were no statistical significance between the CGRP levels of the nasal septal cartilages in the two groups（P〉0.05）, neither did that of the nasal septal bones in the two groups（P〉0.05）. Conclusion： The SP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. The VIP level of the nasal septum in the perennial allergic rhinitis patients was higher than that in the normal controls, which was more obvious in the nasal septal cartilages. There were no statistical significance between the CGRP levels of the nasal septum in the perennial allergic rhinitis pa tients and the normal controls.

关 键 词：变应性鼻炎 鼻中隔 放射免疫分析 P物质 血管活性肠肽 降钙素基因相关多肽 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]