心血管支架材料生物力学及生物相容性与支架置入后血管再狭窄  

Biomechanics and biocompatibility of cardiovascular stent materials and restenosis following stent implantation

作　　者：谢潮鑫[1] 孟猛[1] 曾伟杰[1] 钟磊[1] 魏春霞[1] 罗佼[1] 

机构地区：[1]解放军第四二一医院肾内科,广东省广州市510318

出　　处：《中国组织工程研究与临床康复》2009年第13期2565-2568,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：血液和组织相容性是人工心血管材料广泛应用中的主要问题之一。一种性能优良的心血管支架应具备良好的生物相容性、合适的扩张比、足够的柔韧性和顺应性、材料易消毒、微环境易控制性等,置入后必须保证能让细胞很好的贴附生长,具有良好的细胞亲和性。经皮冠状动脉介入治疗是冠状动脉粥样硬化性心脏病治疗的一个里程碑,但支架内再狭窄却严重地限制了经皮冠状动脉介入治疗的发展。支架内再狭窄的机制十分复杂,是多因素共同作用的结果,目前研究仍存在许多难点,只有彻底揭开支架内再狭窄的内在机制,才能有效降低支架内再狭窄的发生率。随着表面技术的迅速发展,可通过对心血管置入材料表面改性来提高材料组织相容性、血液相容性、力学性能及抗腐蚀行为,可为开发性能优良的新型生物可降解材料提供有效方法。Blood compatibility and histocompatibility are important in extensive application of artificial cardiovascular materials. Good cardiovascular stent should have good biocompatibility, appropriate expansion ratio, enough flexibility and compliance, simple disinfection, and controllable microenvironment. In addition, it could support cell attachment. Percutaneous coronary intervention is a breakthrough in treatment of coronary atherosclerotic heart disease. However, in-stent restenosis greatly limits its development. In-stent restenosis is caused by many factors; it remains poorly understood. Therefore, the mechanism of in-stent restenosis becomes important to reduce restenosis incidence. With rapid developing surface technology, surface modification of stent materials may improve blood compatibility, histocompatibility, mechanical property and corrosion resistance, and provide effective methods for developing novel biodegradable materials.

关 键 词：心血管支架 生物力学 生物相容性 冠状动脉再狭窄 

分 类 号：R318[医药卫生—生物医学工程]