恶性疟原虫的基因表达控制  

Research progress on control of gene expression in Plasmodium falciparum

作　　者：张娜[1] 尹继刚[1] 陈启军[1,2] 

机构地区：[1]吉林大学人兽共患病研究所,教育部重点实验室,长春130062 [2]中国医学科学院病原生物学研究所,寄生虫学联合实验室,北京100071

出　　处：《国际医学寄生虫病杂志》2009年第2期91-94,共4页International JOurnal of Medical Parasitic Diseases

基　　金：国家重点基础科技发展计划（973）（2007CB513100）

摘　　要：由疟原虫感染引起的疟疾是一种严重危害人体健康的寄生虫病，在发展中国家造成巨大的经济损失。恶性疟原虫基因组测序的完成，使实验室可以更进一步研究恶性疟原虫的基本生物学过程，其中恶性疟原虫基因表达调控受到重视。严格的基因表达模式控制着疟原虫的分化，随着一些假定转录因子的鉴定，恶性疟原虫的基因表达调节机制可能与真核生物不一样。该文对恶性疟原虫基因调节的最新研究进展进行了综述。Malaria is a major threat to human life and health, and causes economic damage to the endemic countries, particularly those in the developing world. Recent genome sequencing projects of Plasmodium falciparum have facilitated the laboratory studies to gain insights into basic biological processes, especially con- trolling gene expression. A rigorously regulated gene expression pattern controls the differentiation of the parasite from one stage to another during its life cycle. As some hypothetical transcription factors have been identified, the mechanism of gene expression of Plasmodiumfalciparum may be different from other eukaryotes. Here we reviewed recent advances in the study of epigenetic gene regulation in Plasmodium falciparum.

关 键 词：疟原虫 恶性 基因表达 组蛋白密码 

分 类 号：R382.31[医药卫生—医学寄生虫学] R730.2[医药卫生—基础医学]