疟原虫感染诱导的蚊虫免疫相关基因及其用于转基因蚊的研究  

Immune genes activated by the Plasmodium infection and its usefulness in researches of genetically modified mosquito

作　　者：李云华[1] 朱淮民[1] 

机构地区：[1]第二军医大学病原生物学教研室,上海200433

出　　处：《国际医学寄生虫病杂志》2009年第2期95-100,共6页International JOurnal of Medical Parasitic Diseases

基　　金：基金项目：国家重点基础研究发展计划（973计划,2007CB513107）科技部自然资源项目（2004DKA30480,2005DKA21100）

摘　　要：按蚊与疟原虫的相互作用是按蚊抵抗疟原虫感染的分子基础，疟原虫的感染诱导了蚊体内大量免疫相关基因的转录激活，进而干扰疟原虫在蚊体内的发育。由于目前尚缺乏控制疟疾的有效方法，应用抗疟基因构建转基因蚊已经成为控制疟疾的候选技术之一，该文讨论了免疫相关分子及转基因蚊的研究进展。The molecular basis of mosquito refractory to malaria is mainly determined by the Anopheles-Plasmodium interactions. Large numbers of immune-responsive genes in the mosquito are activated by the invading malaria parasites and their development in mosquitoes is strongly interrupted by these immune responses. Due to the lack of the effective ways to control malaria, the construction of genetically modified mosquitoes might become one of the technologies to control malaria. This review summarized the recent research on some immune-responsive genes and its application in the genetically modified mosquitoes.

关 键 词：疟原虫 蚊 免疫基因 转基因蚊 

分 类 号：R384.1[医药卫生—医学寄生虫学] R581.1[医药卫生—基础医学]