临床药动学给药个体化系统的研制及应用  

Development and application clinical pharmacokinetics and individualizing dosage regimens system

作　　者：夏东亚[1,2] 申晓环 刘宝庆[1,2] 隋因[1,2] 唐云彪 

机构地区：[1]沈阳军区总医院药剂科 [2]中国人民解放军第202医院

出　　处：《中国药学杂志》1998年第4期229-232,共4页Chinese Pharmaceutical Journal

摘　　要：目的：为利用临床常规监测的血药浓度数据估算病人的个体药动学参数，优化给药方案，设计、研制了临床药动学给药个体化系统（ＣＰＫＤＰ程序）。方法：依据群体药动学原理及Ｂａｙｅｓ公式，ＣＰＫＤＰ程序用ＦＯＸＰＲＯ２．６和ＢＯＲＬＡＮＤＣ＋＋３．１开发，在希望汉字系统ＵＣＤＯＳ５．０平台上运行。结果：ＣＰＫＤＰ程序适用于具有不同药动学特征的多种药物，适用于不同给药途径的单剂量或多剂量给药。在群体药动学参数的基础上，结合病人个体特征，以１，２个血药浓度作为反馈，即可拟合估算个体药动学参数，优化给药方案。结论：经初步应用，ＣＰＫＤＰ程序是应用Ｂａｙｅｓ反馈法开展临床个体化给药工作非常实用的工具。OBJECTIVE: To design and develop a clinical pharmacokinetics and individual drug dosage regimens system (CPKDP program) for estimating individual pharmacokinetic parameters and optimizing individualizing dosage regimens using routine clinical data of plasma levels. METHODS: According to the principle of population pharmacokinetics and Bayes' formula, CPKDP program was written with FOXPRO 2.6 and BORLAND C++ 3.1, and was run on 486 microcomputer with UCDOS 5.0. RESULTS: CPKDP program was adapted for drugs with different characteristics of pharmacokinetics, and for single dose or multiple dose administration. Using 1 or 2 measured drug concentrations, individual patient's pharmacokinetic parameters were estimated based on populationaverage pharmacokinetic parameters. CONCLUSION: CPKDP program is applied for estimating pharmacokinetic parameters and optimizing drug therapy in individual patients.

关 键 词：个体化给药 临床药动学 计算机程序 

分 类 号：R969.1[医药卫生—药理学]