宿主自身卵巢与移植胚鼠卵巢的生长发育相互影响的实验研究  

Experimental Study on the Growth and Development Relationship between Ovaries of Hosts and Transplanted Fetal Ovarian Tissues in Rats

作　　者：秦海燕[1] 黄学惠[2] 马芳[1] 

机构地区：[1]昆明医学院,云南昆明650031 [2]昆明医学院第一附属医院妇科,云南昆明650032

出　　处：《昆明医学院学报》2009年第3期12-15,共4页Journal of Kunming Medical College

基　　金：云南省教育厅科学基金资助项目(4041163)

摘　　要：目的探讨宿主自身卵巢与移植胚鼠卵巢的生长发育是否存在相互影响的关系.方法将胚鼠卵巢分别移植至单侧卵巢摘除及去势雌鼠皮下,观察同时存在的自身卵巢对移植物生长发育有无影响,以及是否受移植物影响.结果单摘移植的宿主卵巢黄体总体均数较高,与单侧卵巢摘除组比较差异有统计学意义(P<0.05).去势宿主体内移植的胚胎卵巢中的原始卵泡会继续生长发育出各阶段卵泡,而单摘受者体内的移植物停止发育,抑或纤维化吸收.结论宿主体内卵巢与移植胚鼠卵巢卵泡存在相互竞争关系,自身卵巢较移植物卵泡更具优势.Objective To discuss whether follicles in situ ovaries and in grafts influence the growth and development of each other. Methods We designed the experiment to investigate the simultaneous ovary remained whether affects or is affected by grafted recipients that remained one of in situ ovaries, fetal ovarian tissue after transplantation of fetal ovarian tissue to or that received oophorotomy respectively. Result Graft in recipients that had removed one of in situ ovaries growed and developed with more population mean of corepus luteum, there was statistical difference between different groups （P 〈 0.05）. Graft in recipients that removed their own ovaries could grow and develop with all phases of follicles, and that remained one own ovary stopped continuing development, or even absorbed by fibrosis. Conclusions Follicles in situ ovaries and in grafts compete with each other. Follicles in ovaries of recipients evidently have more advantages than follicles in grafts.

关 键 词：胚胎卵巢 异位移植 大鼠 生殖 内分泌 

分 类 号：R711[医药卫生—妇产科学]