血浆VEGF水平与糖尿病视网膜病变的关系  

The Relationship between Plasma VEGF Levels and Diabetic Retinopathy

作　　者：杨莹[1] 张瑛[1] 李显丽[1] 郭翀[2] 王玉明[2] 徐凡[1] 

机构地区：[1]昆明医学院第四附属医院内分泌科,云南昆明650032 [2]昆明医学院第一附属医院检验科,云南昆明650031

出　　处：《昆明医学院学报》2009年第3期21-24,共4页Journal of Kunming Medical College

基　　金：云南省教育厅资助项目(2007Z40625);云南省第二人民医院基金资助项目(2008yk009)

摘　　要：目的探讨血管内皮生长因子(VEGF)与糖尿病视网膜病变(DR)的关系.方法应用定量双抗体夹心酶联免疫(ELISA)法检测290例2型糖尿病患者(其中单纯型糖尿病视网膜病变即NPDR组112例、增殖型糖尿病视网膜病变即PDR组70例、无视膜病变糖尿病患者即NDR组108例)的血浆VEGF水平与50例正常对照者(NC)进行比较.结果(1)糖尿病患者VEGF水平明显高于NCP<0.001;(2)DR组VEGF水平显著高于NDR组P<0.01,PDR组显著高于BDR组,P<0.001;(3)Logistic回归分析表明VEGF是DR发生的危险因素.结论血浆VEGF可能对糖尿病视网膜病变发生、发展起重要作用.Objective To investigate the relationship between plasma vascular endothelial growth factor （VEGF） levels and diabetic retinopathy. Methods The plasma VEGF levels were detected by enzyme linked immunosorbent assay （ELISA） in 290 type 2 diabetetic patients （including 112 non-proliferative diabetic retinopathy in NPDR group, 70 proliferative diabetic retinopathy in PDR group, 108 non-diabetic retinopathy NDR group） and 50 healthy nondiabetic subjects. Results （1） There was significant difference between diabetes patients and normal. （2） There was significant difference among different diabetic retinopathy groups. （3） Logistic regression analysis showed that the plasma level of VEGF was significantly correlated to diabetic retinopathy. Conclusion The plasma VEGF may contribute to the incidence and development in diabetic retinopathy.

关 键 词：糖尿病 糖尿病视网膜病变 血管内皮生长因子 

分 类 号：R587.1[医药卫生—内分泌]