哺乳动物氨基酰-tRNA合成酶复合物中三个辅助因子在分子信号网络中的重要作用  

The Important Role of Three Auxiliary Factors of Mammalian Aminoacyl-tRNA Synthetase Complex in The Cellular Signaling Network

作　　者：贺然[1] 王恩多[1] 

机构地区：[1]中国科学院上海生命科学研究院,生物化学和细胞生物学研究所,分子生物学国家重点实验室,上海200031

出　　处：《生物化学与生物物理进展》2009年第4期398-402,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目(30570380,30670463)~~

摘　　要：氨基酰-tRNA合成酶是一类古老而保守的蛋白质,它们催化蛋白质生物合成的第一步反应.哺乳动物细胞内存在一个由8种氨基酰-tRNA合成酶和3种辅助因子组成的氨基酰-tRNA合成酶复合物.近年来,陆续发现该复合物中的3个辅助因子p43、p38和p18在复合物外的多种生命活动中扮演着重要角色:辅助因子p43是细胞因子内皮单核细胞激活肽Ⅱ的前体,参与了血管生成和细胞凋亡等许多生命过程;辅助因子p38在肺部发育中至关重要,同时它在神经细胞中的不正确积累可能与帕金森病有关.更有趣的是,辅助因子p38和p18可以在时空上高度有序地通过不同的通路参与细胞对DNA损伤的修复.这些研究增加了对于氨基酰-tRNA合成酶和细胞内大分子信号网络之间关系的认识,并将促进对该领域的研究与发展.Aminoacyl-tRNA synthetase catalyzing the first reaction of protein biosynthesis. In mammalian cells, eight aminoacyl-tRNA synthetases （aaRSs） and three auxiliary protein factors form a macromolecular aminoacyl-tRNA synthetases complex （aaRS complex）. The three nonsynthetase protein factors, namely, p43, p38, and p18 were found to be involved in many other important life activities besides their roles in the complex. The auxiliary factor p43 was the precursor of endothelial monocyte activating polypeptide Ⅱ （EMAP Ⅱ ）, which involved in angiogenesis and apoptosis. The auxiliary factor p38 was crucial for the development of lung, and its abnormal accumulation in neuron would be related to the Parkinson＇ s disease. The auxiliary factor p38 and p18 could promote the repair of DNA damage via different pathways in a highly organized way. All these breakthroughs enhance our understanding about the interaction between the aaRS complex and the macromolecular signaling network and promote the studies on this field.

关 键 词：哺乳动物 氨基酰-TRNA合成酶 辅助因子 DNA损伤修复 信号网络 

分 类 号：Q71[生物学—分子生物学]