银杏酸和槚如酸结构修饰及其衍生物活性的研究进展  

Advance in the study on derivatives of ginkgolic acids and anacardic acids

作　　者：刘方[1] 杨小明[1] 

机构地区：[1]江苏大学化学化工学院,镇江212013

出　　处：《中国新药杂志》2009年第5期410-412,共3页Chinese Journal of New Drugs

基　　金：江苏省社会发展基金(BS2005042);镇江市社会发展基金(SH2006071);江苏大学高级人才启动金(05JDG024)

摘　　要：银杏酸(ginkgolic acids)是6-烷(烯)基水杨酸衍生物,具有多种生物活性,存在于银杏的叶、果和外种皮中;类似的化合物亦存在于槚如树的果实中。作者对近年来这类化合物的结构修饰及其衍生物的生物活性进行综述,介绍几种修饰途径,并将新合成的物质与银杏酸比较活性,结果显示有良好的效果,旨在为今后银杏酸的进一步开发利用提供参考。Ginkgolic acids existing in leaves,nuts and sarcocarps of Ginkgo biloba,are derivatives of 6-alkylsalicylic acids.Ginkgolic acids have notable bioactivities.The class of compounds also exists in fruit of Anacardium occidentale.Here,we summarized the structural modification of the class of compounds and biological activities of the derivatives.Several synthetic routes were analyzed,and the activities of anacardic acids＇ derivatives and anacardic acids were compared.These derivatives show a better effect.This article provides reference for the utilization of ginkgolic acids.

关 键 词：银杏酸 槚如酸 结构修饰 生物活性 

分 类 号：R284.3[医药卫生—中药学]