1136周期宫腔内夫精人工授精临床因素的分析  

Analysis on pregnancy outcome in 1136 cycles of intrauterine insemination

作　　者：侯翠[1] 王文军[1] 张清学[1] 李予[1] 麦美琪[1] 陈静华[1] 欧阳能勇[1] 陈虹[1] 

机构地区：[1]中山大学附属第二医院生殖中心,广东广州510120

出　　处：《中国妇幼保健》2009年第11期1521-1523,共3页Maternal and Child Health Care of China

摘　　要：目的:对影响宫腔内夫精人工授精(Intrauterine insemination,IUI)妊娠率的因素进行分析。方法:对接受夫精宫腔内人工授精治疗的651例不孕患者1 136周期的临床资料进行回顾性分析,主要分析不同的促排卵方案、IUI周期数、子宫内膜形态、内膜厚度等与妊娠率的关系。结果:1 136周期的IUI中妊娠周期93周期,周期妊娠率8.19%;<30岁、30～35岁,和>35岁妊娠率分别是8.80%、7.69%和5.42%;不同的促排卵方案(CC、hMG/hCG、hCG)的妊娠率分别为10.00%、9.00%和7.46%;hCG日内膜厚度为<8 mm、8～14 mm、>14 mm,妊娠率分别为5.61%、8.70%和12.70%;hCG日或出现LH峰当日子宫内膜形态为A型、B型、C型时,妊娠率分别是9.63%、4.55%和8.00%;重复周期IUI对提高妊娠结局差异无统计学意义。结论:施行IUI女方的年龄是影响IUI妊娠率的主要因素;多次重复周期IUI并不能显著改善妊娠结局;不同促排卵方案的妊娠结局差异无统计学意义。Objective： To analyse the effect factors of pregnancy rate after intrauterine insemination （IUI） with husband＇s sperm. Methods： Clinical data of 651 couples undergoing 1 136 IUI cycles were analysed retrospectively. The relationship between different ovulation induction protocols, cycles of IUI, endometrial patterns, endometrial thickness and pregnancy rate were observed. Results： 93 pregnancy cycles among 1 136 cycles of IUI were found, The cycle pregnancy rate was 8.2%. The pregnancy rates of women below 30 years, aged 30 - 35 years old and beyond 35 years were 8.80% , 7.69% and 5.42% ; the pregnancy rates of different ovulation induction protocols （ CC, hMG/hCG, hCG） were 10. 00% , 9. 00% and 7. 46% ; the pregnancy rates of different endometrial thickness （ 〈 8 ram, 8 - 14 ram, 〉 14 ram） at the day ofhCG injection were 5. 61% , 8.70% and 12.07% ; the pregnancy rates of different endometrial patterns （A, B and C） at the day ofhCG injection or LH surge were 9. 63% , 4. 55% and 8% ; there was no correlation between high repeat intrauterine insemination cycles and pregnant outcomes. Conclusion： The age of female patients is the major effect factor of pregnancy rate; high repeat intrauterine insemination cycles cant improve the pregnant outcomes; There is no correlation between ovulation induction protocols （CC, hMG/ hCG, hCG） and pregnant outcomes.

关 键 词：人工授精 妊娠率 子宫内膜 促排卵 年龄 

分 类 号：R715[医药卫生—妇产科学]