流感病毒受体在三种动物气管和肺脏分布的组织化学检测  

Distribution of influenza virus receptors in trachea and lung of three animal detected by histochemistry

作　　者：宁章勇[1] 刘雪梅[2] 罗敏意[1] 亓文宝[1] 焦培荣[1] 廖明[1] 

机构地区：[1]华南农业大学兽医学院,广东广州510642 [2]泰安卫生学校,山东泰安271018

出　　处：《中国动物检疫》2009年第4期44-47,共4页China Animal Health Inspection

基　　金：教育部创新团队项目(IRT0723);教育部新世纪优秀人才支持计划(NCET-06-0752);国家科技支撑计划(2006BAD06A16-2);广东省创新团队项目(5200638);广东省科技计划项目(2006B21101001)

摘　　要：利用凝集素组织化学染色的方法,对岭南黄鸡、番鸭和BALB/C小鼠的气管和肺脏进行了流感病毒受体分布的检测。结果表明:在岭南黄鸡、番鸭和小鼠的气管粘膜层、粘膜下层、肺脏的细支气管和肺泡上皮细胞均有禽流感病毒受体的分布。番鸭和小鼠气管和肺脏的人流感病毒受体的分布范围和细胞类型与禽流感病毒受体的分布稍有差异,岭南黄鸡气管和肺脏未检测到人流感病毒受体的分布。研究结果为探讨流感病毒的感染机制和宿主特异性的差异提供了基础数据。The distributions of influenza virus receptors were investigated in trachea and lung of Lingnan yellow chicken, Muscovy duck and BALB/C mice by lectin histochemistry. The results showed that avian influenza virus receptor was detected in mucosa, sub mucosa of trachea, bronchioles and epithelial cells of pulmonary alveoli of lung tissue in three animals. Distribution of human influenza virus receptor of trachea and lung was similar to avian influenza virus receptor except the extent and cell types in Muscovy duck and BALB/C. No detection of human influenza virus receptors of trachea and lung tissues in Lingnan yellow chicken. The results provided the basic data for research of infection mechanism and specificity of host of influenza virus.

关 键 词：气管 肺脏 流感病毒受体 分布 

分 类 号：S852.165[农业科学—基础兽医学]