苯并色烯类化合物合成方法的探讨  

The Exploration of the Synthetic Method for Benzochromenopyrimidine Derivatives

作　　者：金劲松[1,2] 宋森川[3] 林伟忠[2] 黎逢权[2] 陈国强[2] 李红山[3] 宋化灿[2] 

机构地区：[1]广东中烟工业有限责任公司,广东广州510610 [2]中山大学化学与化学工程学院,广东广州510275 [3]嘉应学院化学系,广东梅州514015

出　　处：《中山大学学报（自然科学版）》2009年第2期66-70,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：广东省科技厅科技计划资助项目(2003C103006;2007B060401068);国家重点实验室开放课题资助项目(2007-01)

摘　　要：以取代苯甲醛、丙二腈和2-萘酚(或2,7-萘二酚)为原料合成出了3-氨基-2-氰基-1-(4-取代苯基)-1H-苯并[f]色烯类物质,后者在冰醋酸或者醋酸钠催化作用下,乙酸酐中回流,合成出苯并色烯并嘧啶类化合物。这类化合物的关环反应条件易于实施,后处理简单,易于纯化,属于首次报道。A series of benzo [f] chromeno [2, 3-d] pyrimidine derivatives were prepared using acetic acid or sodium acetate as catalyst by the condensationcyclization reaction of acetic anhydride and 2- amino-3-cyanobenzo [f] chromene derivatives which were synthesized by the reaction of substitutedbenzoaldehyde, malononitrile and naphthalen-2-ol. This cyclization reaction of 2-amino-3- cyanobenzo [f] chromene derivatives could be finished easily and the product was easily purified, and this method is reported for the first time.

关 键 词：合成 苯并[f]色烯类化合物 苯并[f]色烯并嘧啶类化合物 

分 类 号：O621.3[理学—有机化学]