淋巴细胞上钾离子通道及其调控  

CHARACTION AND REGULATION THE POTASSIUM ION CHANNELS ON LYMPHOCYTES

作　　者：傅涛[1] 郝选明[1] 

机构地区：[1]华南师范大学体育科学学院,广东广州510006

出　　处：《内蒙古医科大学学报》2010年第S1期47-51,共5页Journal of Inner Mongolia Medical University

基　　金：国家科技支撑计划课题(2006BAK12B02)

摘　　要：淋巴细胞膜上的钾离子通道,在淋巴细胞活化过程中发挥重要作用,是免疫功能调节的重要环节。淋巴细胞膜上的钾离子通道分为2类:电压门控式钾离子通道(Kv)和钙激活的钾离子通道(KCa)。Kv是维持细胞静息膜电位的主要承担者;Kv和KCa分别在细胞活化的启动和维持阶段发挥主要作用;Kv和Cl-通道共同调节细胞容积。对钾离子通道的调节有利于我们对淋巴细胞的发育、活化和增殖等多种生物学过程的进一步了解。There are increasing evidences to show that potassium ion channels on lymphocytes play a very important role in the regulation of immune functions.In lymphocytes,there are two types of potassium channels on lymphocytel membrane: voltage-gated potassium channel(Kv) and calcium-activated potassium channel(KCa).These channels participate in setting resting membrane potation,and modulation of cell mitogensis,calcium signaling and volum eregulation.The regulation on potassium channels could facilitate us to understand lymphocytic development,activation,proliferation and other biological process.

关 键 词：淋巴细胞 钾离子通道 调控 

分 类 号：R331.1[医药卫生—人体生理学]