栓剂的研究进展与临床应用  

THE RESEARCH PROGRESS AND CLINICAL APPLICATION OF SUPPOSITORY

作　　者：李艳春[1] 刘乐乐[2] 高荣[2] 关云飞[2] 

机构地区：[1]内蒙古巴彦淖尔市医院药剂科,内蒙古临河015000 [2]内蒙古医学院药学院

出　　处：《内蒙古医科大学学报》2010年第S3期33-36,共4页Journal of Inner Mongolia Medical University

基　　金：内蒙古自治区卫生厅资助项目(2006014)

摘　　要：普通栓剂用药后存在峰谷现象、血药浓度不稳定、药物暴露部分易氧化、潮解、变质等缺点。为提高栓剂中药物的生物利用度和稳定性,以及能更好地适应临床或不同药物性质的需要,研究者以控制栓剂中药物的释放为目的,研制出多种类型的新型栓剂。栓剂的种类按其作用分为两种。一种是在腔道起局部作用。另一种是由腔道吸收至血液而发挥全身作用起全身作用。Some shortcomings will appear after taking the common supository such as peak-notch phenomenon,unsteady bllld concentaration,the exposed portion readily oxidized,deliquescence,deteriorate,ect.To improve the bioavaiability and the stability of the suppository,and to adapt to needs for clinical and the property of different medications better,aiming at controlling the release of the agent in the suppository,the researchers have developed may types of new suppository.The supository can be divided into two types by ist action.One of them takes into local effects in the orifice.The other one takes into the general action by absorbed into blood.

关 键 词：栓剂 缓释 应用 

分 类 号：R944[医药卫生—药剂学]