中药复方产复康对小鼠的抗氧化作用研究  

Effect of Chinese Herbal Medicine Chanfukang on Antioxidation in Mice

作　　者：严作廷[1] 王东升[1] 巩忠福[2] 杨国林[1] 谢家声[1] 李世宏[1] 梁纪兰[1] 曾宪成[1] 余四九[3] 

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,兰州730050 [2]中国兽医药品监察所,北京100081 [3]甘肃农业大学动物医学院,兰州730070

出　　处：《中国兽药杂志》2009年第4期11-13,共3页Chinese Journal of Veterinary Drug

基　　金：国家科技攻关项目奶业专项"奶牛主要疫病防治关键技术研究与产业化开发"子课题(编号2002BA518A04)

摘　　要：为了评价产复康的抗氧化作用,用环磷酰胺造成免疫抑制小鼠模型,将产复康分别以10、15、20g/kg体重三个不同剂量给模型小鼠连续灌胃9d后,测定了模型小鼠脾脏和胸腺组织中、总抗氧化能力(TAOC)、超氧化物岐化酶(SOD)和丙二醛(MDA)以及血清溶血素、脾脏和胸腺指数。结果发现产复康分别以10、15、20g/kg体重三个不同剂量均能显著提高环磷酰胺所致免疫抑制小鼠脾脏和胸腺TAOC水平、SOD活性、血清溶血素、脾脏和胸腺指数,而显著降低小鼠脾脏和胸腺MDA水平,且呈剂量-效应关系;正常小鼠单独服用产复康也产生相同结果。结果说明产复康能提高健康小鼠的抗氧化能力。In order to evaluated antioxidation effect of Chinese herbal medicine Chanfukang, The immunity suppression model was established by injection cyclophosphamide, The level of total antioxidation capability （TAOC）, superoxide dismutase （SOD）, malondialdehyde（ MDA）, erythrocytolysin, spleen and thymus index in mice were measured after treated with different Chinese herbal medicine Chanfukang at doses of 15 g/kg alone or 10,15 and 20 g/kg for 9 days respectively by orally injection at immunity suppression model in mice. The results showed that the MDA level of spleen and thymus increased significantly, and the erythrocytolysin, spleen and thymus index, TAOC, SOD activity of spleen and thymus decreased obviously in immunity suppression model. The erythrocytolysin, spleen and thymus index, TAOC level, SOD activity was increased, while the MDA of spleen and thymus de- creased significantly in dose dependent manner after Chanfukang orally injection, the same result was showed Chanfukang orally alone in healthy mice too. The results indicated that Chanfukang can enhance antioxidation capability in healthy and immunity suppression mice.

关 键 词：产复康 小鼠 抗氧化作用 

分 类 号：S859.3[农业科学—临床兽医学]