免疫检测新技术在病原微生物鉴定中的应用分析  

Application of immunological methods for detection of pathogenic microorganism

作　　者：李作生[1] 范泉水[1] 张富强[1] 邱薇[1] 李刚山[1] 郑颖[1] 黄勇[1] 王杰[1] 冯子良[1] 周卫国[1] 王双印[1] 

机构地区：[1]成都军区疾病预防控制中心,云南昆明650032

出　　处：《云南大学学报（自然科学版）》2007年第S3期416-419,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：成都军区"十五"医药卫生计划A类课题(04009)

摘　　要：面对生物恐怖、新现和再现传染病病原体的威胁,为了临床治疗、流行病学调查和公共卫生监督提供依据,迫切需要准确快速的病原体鉴定.分子生物学技术的发展使得融合抗体偶联物的制备成为可能,不仅降低了,而且成本提高了检测敏感性.同时,许多具有准确可靠、敏感性好的成本低、使用简单的免疫检测技术和设备得到改进和发展,并被广泛应用于门诊病人监测、大样品的筛选和环境监测等领域.重点介绍生物战剂和传染病病原体检测鉴定中免疫检测新技术的应用和分析.Because of the threat posed by both BW and emerging or reemerging ID agents, there is a need to rapidly identify such agents in the clinical setting in order to treat the individuals at risk and to improve public health surveillance and epidemiology. Recent developments in molecular biology techniques have made possible the production of fusion antibody conjugates, which may lead to further improvements in the sensitivity and cost of reagents, as well as possibly revolutionizing the production of monoclonal antibodies. At the same time, simple - to - use, inexpensive assay systems have been developed with the necessary reliability, accuracy, and sensitivity to bring immunoassay technology to much more diverse areas such as outpatient monitoring, large screening programs in developing countries, and remote environmental surveillance. This brief review will detail the current state of the art in rapid immunological assays for the detection and identification of BW/ID agents and also offer a look into the future of the technology and its application.

关 键 词：生物战剂 病原微生物 免疫检测 

分 类 号：R392.1[医药卫生—免疫学]