明胶和京尼平粘合自体颗粒骨修复兔桡骨缺损的实验研究  

Autogenous morselized bone adhibited by gelatin and genipin for repair of radial bone defect in rabbit

作　　者：曾荣[1] 吴少科[1] 郭伟韬[1] 谭志[2] 胡资斌[1] 

机构地区：[1]广东医学院附属医院骨外科,广东湛江524001 [2]广东医学院附属医院放射科,广东湛江524001

出　　处：《广东医学院学报》2009年第1期5-8,共4页Journal of Guangdong Medical College

基　　金：广东省社会发展计划项目(No.63043);广东省自然科学基金项目(No.06028967)

摘　　要：目的探讨以明胶和京尼平粘合自体颗粒骨修复新西兰大白兔桡骨缺损的效果,为临床应用提供依据。方法取24只新西兰大白兔制成双侧前臂桡骨中段骨缺损模型,并将切除的骨质磨成颗粒骨,随机分为A、B、C、D 4组,每组为6只,A组为空白组不填充任何材料;B组单纯填充明胶、京尼平;C组单纯植入400 mg自体颗粒骨;D组填充明胶、京尼平+200 mg自体颗粒骨。各组术后2、4、8周时各处死动物兔2只,取材检测,通过观察大体标本、X线片、组织学检查评估骨缺损修复能力。结果在术后各时期,A、B组骨缺损模型均无骨愈合迹象,形成陈旧性骨缺损。术后C、D组均有良好的骨修复效果,但D组在防止颗粒骨移位流失、骨融合程度、新骨形成量、骨塑形改建方面优于C组。结论明胶、京尼平具有粘合自体颗粒骨修复骨缺损的能力。Objective To study the efficacy of autogenous morselized bone with gelatin and genipin for repair of radial bone defect in rabbit. Methods The segmental bone defects of bilateral radiuses were created in 24 New Zealand white rabbits. These rabbits were divided into 4 groups： group A received no implants, while group B, group C and group D were grafted with gelatin and genipin, 400 mg autogenous morselized bone, and 200 mg autogenous morselized bone with gelatin and genipin, respectively. The bone repair was assessed by gross specimen examination, X-ray and histopathology at 2, 4 and 8 weeks. Results The bone defect repair was absent in group A and B, but excellent in group C and D. Position of morseliazed bone, bone fusion, new bone formation and bone moulding in group D were superior to those in group C. Conclusion Addition of gelatin and genipin in autogenous morsdized bone can improve the repair of bone defect.

关 键 词：自体颗粒骨 明胶 京尼平 骨缺损 

分 类 号：R681.7[医药卫生—骨科学]