An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation  

作　　者：Cheng Jiang Qi Dong You 

机构地区：[1]Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Chinese Chemical Letters》2007年第6期647-650,共4页中国化学快报（英文版）

摘　　要：An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77–94% for aromatic aldehydes) and short reaction time (3–8 min).An efficient synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using formic acid as catalyst, from aldehydes, β-ketoester and urea(thiourea) without solvent under the irradiation of microwave is described. Compared with the classical Biginelli reaction, this new method has the advantage of good yields (77–94% for aromatic aldehydes) and short reaction time (3–8 min).

关 键 词：Biginelli reaction 3 4-Dihydropyrimidone MICROWAVE SOLVENT-FREE Formic acid 

分 类 号：O644.2[理学—物理化学]