Design, synthesis and molecular docking studies of novel triazole antifungal compounds  

作　　者：Qiu Qin He Ke Li Yong Bing Cao Huan Wen Dong Li Hua Zhao Chao Mei Liu Chun Quan Sheng 

机构地区：[1]School of Pharmacy, Second Military Medical University, Shanghai 200433, China

出　　处：《Chinese Chemical Letters》2007年第6期663-666,共4页中国化学快报（英文版）

摘　　要：Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.Based on the active site of Candida albicans lanosterol 14α-demethylase (CACYP51), novel triazole compounds structurally different from the current triazole drugs were designed and synthesized. In vitro antifungal activities showed that compounds 10, 11, 16 and 20 exhibited strong activities. In addition, compounds 10, 11 and 16 also displayed certain activities against fluconazole-resistant fungi.

关 键 词：Lanosterol 14α-demethylase TRIAZOLE TERT-BUTYL Antifungal activity Fluconazole-resistant 

分 类 号：O626.26[理学—有机化学]