Biocatalytic synthesis of (R)-(-)-mandelic acid from racemic mandelonitrile by a newly isolated nitrilase-producer Alcaligenes sp. ECU0401  

作　　者：Yu Cai He Jian He Xu Yi Xu Li Ming Ouyang Jiang Pan 

机构地区：[1]Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China

出　　处：《Chinese Chemical Letters》2007年第6期677-680,共4页中国化学快报（英文版）

摘　　要：By using acetonitrile as the sole nitrogen source, a microbial strain with high nitrilase activity, named as Alcaligenes sp. ECU0401, was newly isolated from soil, which could enantioselectively transform racemic mandelonitrile into (R)-(?)-mandelic acid, with an enantiomeric excess of >99.9%.By using acetonitrile as the sole nitrogen source, a microbial strain with high nitrilase activity, named as Alcaligenes sp. ECU0401, was newly isolated from soil, which could enantioselectively transform racemic mandelonitrile into (R)-(?)-mandelic acid, with an enantiomeric excess of >99.9%.

关 键 词：Mandelonitrile NITRILASE (R)-()-Mandelic acid SCREENING Alcaligenes sp. ECU0401 

分 类 号：TQ463.2[化学工程—制药化工]