Effects of Dynamic Changes in Ultrasound Attenuation and Blood Perfusion on Lesion Formation of Multiple-focus Pattern during Ultrasound Surgery  

作　　者：章琛曦 白景峰 陈亚珠 

机构地区：[1]Inst.of Biomedical Instrument,Shanghai Jiaotong Univ.

出　　处：《Journal of Shanghai Jiaotong university(Science)》2007年第4期537-544,共8页上海交通大学学报（英文版）

基　　金：The National Natural Science Foundation ofChina (No 30500124);Shanghai Key Tech-nologies R&D Program of China ( No05DZ19509)

摘　　要：A nonlinear finite-element program was developed to simulate the dynamic evolution of coagulation in tissue considering temperature and thermal-dose dependence of the ultrasound attenuation and blood perfusion rate. The effects of these dynamic parameters on the lesion formation were investigated in the particular case of ultrasound hepatic ablation with bi-focus intensity pattern. The results of simulations were compared that incorporate dynamic changes of ultrasound attenuation and perfusion and results that neglect these effects. The result shows that thermal-dose-dependent ultrasound attenuation is the dominating factor in the full dynamic model. If the dynamic ultrasound attenuation is ignored, a relatively significant underestimation of the temperature rise appears in the focal plane and the region next to the focal plane, resulting in an underestimation in predicting diameter of coagulation. Higher heating intensity leads to greater underestimation.A nonlinear finite-element program was developed to simulate the dynamic evolution of coagulation in tissue considering temperature and thermal-dose dependence of the ultrasound attenuation and blood perfusion rate. The effects of these dynamic parameters on the lesion formation were investigated in the particular case of ultrasound hepatic ablation with bi-focus intensity pattern. The results of simulations were compared that incorporate dynamic changes of ultrasound attenuation and perfusion and results that neglect these effects. The result shows that thermal-dose-dependent ultrasound attenuation is the dominating factor in the full dynamic model. If the dynamic ultrasound attenuation is ignored, a relatively significant underestimation of the temperature rise appears in the focal plane and the region next to the focal plane, resulting in an underestimation in predicting diameter of coagulation. Higher heating intensity leads to greater underestimation.

关 键 词：ULTRASOUND phased arrays finite element TEMPERATURE-DEPENDENCE thermal-dose-dependence DYNAMIC blood PERFUSION DYNAMIC ULTRASOUND attenuation 

分 类 号：R616[医药卫生—外科学]