小气道病变(SAD)的发病机制及戒烟干预研究  

The studay of machine-made and interfrence that give up smoking in Small airway disease(SAD)

作　　者：王建俊[1] 王金鹏[1] 沈超[1] 云清英 孔令敏[1] 李慧梅[1] 王岷 

机构地区：[1]济南铁路局中心医院,济南250001

出　　处：《医学检验与临床》2005年第3期21-22,39,共3页Medical Laboratory Science and Clinics

摘　　要：目的SAD是慢性阻塞性肺疾病(COPD)的早期病理过程,抽烟是病变的主要原因,本研究探讨其发病机制并进行戒烟干预。方法对济南铁路局2002年健康查体检出SAD病人随几抽取50例(抽烟42例非抽烟8例),与非SAD职工40例进行研究,观察细胞因子TNF-α、IL-8、TGF-β1的变化;对抽烟SAD人群劝其戒烟,观察1个月、3个月时以上细胞因子的变化。结果SAD病人与非SAD组三种细胞因子TNF-α、TGF-β1、IL-8细胞因子差异显著,P<0.05;接受戒烟1个月的SAD病人TNF-α、IL-8下降明显,P<0.05;TGF-β1也降低,但无显著意义,P>0.05,接受戒烟3个月病人TNF-α、IL-8、TGF-β1均下降明显,P<0.05。结论TNF-α、TGF-β1、IL-8介导的网络反应在SAD的发生过程中起重要作用;戒烟可明显降低以上细胞因子的产生,减少SAD的形成,有效控制COPD。Objective Small airway disease(SAD) is the early pathological stage of COPD,Smoking is the important reason. In this study we investigate the occasion of SAD.Method To study on the change of cytokines(TNF-α、TGF-β_1、IL-8) of SAD palients and non-SAD people(all people come from the health chack of Jinan Rialway centrer hospital).Dividing SAD group 50cases(Smoking 42cases,non-Smoking8cases),non-SAD group 40cases,We ask the Smoking SAD patients to give up Smoking,then study the change of cytokines at one month and three month.Result There is prominent difference on cytokines level such as TNF-α TGF-β_1 IL-8 between SAD patients and non-SAD people,P<0.05. In one month,The 42cases of giving Smoking SAD patients TNF-α、IL-8d down prominently P,<0.05,However TGF-β_1 can not remarkable changes,P>0.05;in the three month cytokines of TNF-α、TGF-β_1、IL-8 change remarkable,P<0.05. Conclusion TNF-α、TGF-β_1、IL-8 play an importan rule in SAD patients.Giving up Smoking can effectively reduce the non-special inflammation,and decreasing the SAD incidence.

关 键 词：小气道疾病 细胞因子 发病机制 戒烟治疗 

分 类 号：R563.9[医药卫生—呼吸系统]