钌(Ⅱ)多吡啶配合物的合成、表征及其与DNA作用研究  

A Study on Synthesis,Characterization and DNA-binding of Ruthenium(Ⅱ)complex:[Ru(bpy)_2(ipbh)](ClO_4)_2

作　　者：刘云军[1] 梅文杰[1] 王睿杰[1] 简柳清 王娜[1] 曾宪栋[1] 

机构地区：[1]广东药学院,广州510240

出　　处：《中国科技论文》2006年第1期73-75,共3页China Sciencepaper

摘　　要：本文设计合成了钌(Ⅱ)多吡啶配合物[Ru(bpy)_2(ipbh)]^(2+)(bpy=2,2′-联吡啶,ipbh=3-1-氢-咪唑并[4,5-f]邻菲咯啉-1-苯基二恶烷)。采用元素分析,质谱和~1HNMR 对其进行表征。用紫外-可见吸收光谱、荧光光谱、粘度测试和 DNA 熔点变化研究配合物与 DNA 作用,结果表明配合物与 DNA 之间通过插入作用结合。In this study,the DNA-binding of ruthenium(H)mixed-ligand complex containing 2,2-bipyridine [Ru(bpy)_2(ipbh)(ClO_4)_2(bpy=2,2′-bipyridine,ipbh=3-(1H-Imidazo[4,5-f][1,10]phenanthrolin2-yl)-1-benzodioxane) has been synthesized and characterized by elemental analysis,ES-MS and ~1H-NMR spectra.The interaction of the complex with calf thymus DNA(CT-DNA)was investigated by absorption titration,thermal denaturation,viscosity measurements.The results suggest that the complex binds with CT-DNA by intercalation mode.

关 键 词：钌(Ⅱ)配合物 粘度测试 DNA 结合 

分 类 号：O627[理学—有机化学]