复方丹参注射液对室性心律失常心内膜MAP的影响  

The offect of salvia miltiorrhiza injection on epicardiom MAP

作　　者：刘希秀[1] 肖业伟[1] 冯志强[1] 钱知勉[2] 盘强文[1] 

机构地区：[1]泸州医学院生理教研室,四川泸州646000 [2]山东滨州医学院人解与组胚教研室

出　　处：《四川生理科学杂志》2009年第1期11-13,共3页Sichuan Journal of Physiological Sciences

基　　金：四川省教育厅青年基金项目060201038

摘　　要：目的:探讨丹参注射液对室性心律失常时兔心内膜MAP的变化,试图揭示其抗心肌缺血致心律失常作用的机制。方法:2O只家兔,随机分为对照组和丹参组,在心肌缺血背景下致心律失常前后分别记录、检测各项观察指标,作前后对照和组间比较。结果:在心律失常前后,对照组平均心率均低于丹参组;与对照组比较,丹参组在心律失常前后,振幅差异不具有统计学意义,但二组自身心律失常前后比较具有统计学意义;对照组最大上升速度,高于自身心律失常后(P<0.05),丹参组差异不具有统计学意义;对照组与丹参组在心律失常前APD90均低于自身心律失常后(P<O.05),心律失常前,丹参组APD90略低于对照组,但无统计学意义,而在心律失常后,对照组APD90高于丹参组,具有统计学意义。结论:丹参能提高心内膜心肌耐受缺血的能力,起到了ATP敏感性钾通道开放剂效应,这可能是丹参对心肌缺血保护作用具有增强效应电生理基础。To investigate salvia miltiorrhiza injection to ventricular arrhythmia when the rabbit epicardium monophasic action potential changes, to promulgate its anti-myocardium ischemia mechanism of indvcing arrhythmia. Methods： Twenty rabbits were divided into ①the control group, ②the Salvia miltiorrhiza group. The changes of each observation were recorded, under the myocardium ischemia background to cause the arrhythmia. Results： The control group and the salvia miltiorrhiza group in prear- rythmia, the average heart rate, MAPA, the maximum ascending velocity, are higher than arrythmia （P〈0. 05） ; The control group and the salvia miltiorrhiza group APD90 are lower than prearrythmia latter （P〈0. 05）; Around the arrhythmia, the control group and the Salvia Miltiorrhiza group compare, various targets P〈0. 05, has statistics significance. Conclusion： Salvia mihiorrhiza injection can improve to burden ischemia myocardium ability, get up the ATP-sensitive potassium channel open medicinal preparation effect. These may be electrophysiologic basis that Salvia miltiorrhiza injection can increase effect about cardio-protection of iscbemia in ventricular myocytes.

关 键 词：丹参 室性心律失常 心内膜 MAP 

分 类 号：R285.5[医药卫生—中药学]