冠心病合并糖尿病患者血同型半胱氨酸、铜水平的相关性研究  

Correlation between Plasma Total Homocysteine and Copper in Patients with coronary artery disease complicated with diabetes mellitus

作　　者：唐礼江[1] 陈晓锋[1] 沈卫峰[2] 江建军[1] 薛迎生[1] 陈丽娟[1] 杜于茜[1] 陈世勇[3] 

机构地区：[1]浙江省温州医学院附属台州医院心血管内科,317000 [2]上海第二医科大学附属瑞金医院心脏科 [3]浙江省温州医学院附属台州医院检验科,317000

出　　处：《介入放射学杂志》2004年第S2期52-54,共3页Journal of Interventional Radiology

摘　　要：目的　探讨冠心病合并糖尿病患者血同型半胱氨酸、铜的水平及两者的相关性。方法　以 31例冠心病合并 2型糖尿病患者为研究对象 (糖尿病组 ) ,以同期不合并糖尿病的冠心病患者 36例为对照组 (非糖尿病组 ) ,另选择健康对照组 30例 ,测定外周血同型半胱氨酸、铜浓度、体重指数和血脂。结果　糖尿病组血Hcy、Cu ,分别为 (18.8± 3.5 ) μmol L、(2 1.1± 3.8) μmol L ,高于健康对照组 ,分别为(10 .7± 2 .3)、(16 .8± 2 .7) μmol L(P <0 .0 1)和非糖尿病组 ,分别为 (15 .6± 1.9)、(14 .8± 2 .2 ) μmol L(P <0 .0 5 ) ;非糖尿病组Hcy高于健康对照组 (P <0 .0 1) ,而Cu水平与对照组差异无显著性 (P >0 .0 5 )。冠心病合并糖尿病组患者血Hcy与Cu呈正相关 (P <0 .0 1)。Objective To investigate the Correlation between Plasma Total Homocysteine and Copper in Patients with coronary artery disease complicated with diabetes mellitus. Methods 31 pateints with coronary artery disease complicated with diabetes mellitus were studied. 36 age-matched and gender-matched patients with coronary artery disease not complicated with diabetes mellitus and 30 normal subjects were served as control groups. The concentrations of copper and total homocysteine was determined and compared. Results The concentration of copper and total homocysteine was significantly highter in the patients with coronary artery disease complicated with diabetes mellitus (18.8±3.5 μmol/L、21.1±3.8 μmol/L, respectively) than in the patients with coronary artery disease not complicated with diabetes mellitus (15.6±1.9、14.8±2.2 μmol/L, respectively) (P<0.01)and the healthy control subjects (10.7±2.3、16.8±2.7 μmol/L, respectively)(P<0.01). Copper was positively correlated with plasma total homocysteine in patients with coronary artery disease complicated with diabetes mellitus (P<0.01).Conclusions Our findings suggest that Hyperhomocysteinemia increasing risk of coronary artery disease in patients with diabetes mellitus may be related to copper-dependent interactions.

关 键 词：冠心病 糖尿病 同型半胱氨酸 铜 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]