小剂量美托洛尔治疗充血性心力衰竭对血浆脑钠肽水平的影响  

Influence on plasma brain natriuretic peptide level by use of low dose metoprolol for congestive heart failure

作　　者：孙静[1] 钱安斌[1] 

机构地区：[1]浙江省宁波市第一医院内科,315000

出　　处：《介入放射学杂志》2004年第S2期169-171,共3页Journal of Interventional Radiology

摘　　要：目的　观察小剂量美托洛尔治疗充血性心力衰竭后 ,患者血浆脑钠肽 (BNP)水平的改变。方法　选择心功能Ⅲ～Ⅳ级心衰患者 31例 ,在常规抗心衰基础上加用小剂量美托洛尔 ,观察治疗前后血浆脑钠肽水平的变化。结果　心率明显减慢 ,心胸比和血压均较治疗前降低 ,左室舒张末期内径(LVDd)缩短 ,而左室射血分数 (LVEF)则较治疗前升高 ,应用美托洛尔后BNP值明显降低。结论　小剂量倍他乐克治疗充血性心力衰竭 (CHF) ,总有效率达 80 %以上 ,且BNP明显下降。Objective to observe plasma Brain Natriuretic Peptide level by use of low dose Betaloc for congestive heart failure.Methods We chose 31 heart failure patients with Ⅲ～Ⅳ New York Heart Association (NYHA)functional classification,and used low dose Betaloc on the basis of traditional treatment,then observed the changement of plasma Brain Natriuretic Peptide level during treatment. Results After treatment,patients' heart rate, blood pressure ,cardio-thoracic ratio and LVDd all descended,but LVEF increased.The value of BNP declined obviously,after the use of the Betaloc.Conclusions We treated congestive heart failure with low dose Betaloc,the availability ratio was more than 80%,and the value of BNP declined obviously.It implied dynamic monitoring plasma Brain Natriuretic Peptide was helpful in understanding treatment effect and prognosis.

关 键 词：脑钠肽 美托洛尔 充血性心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]