不同温度下血管舒张及收缩反应的差异及其功能变化  

Affection on vascular vasomotor and function at different temperature

作　　者：江科[1] 王建军[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胸外科,武汉430030

出　　处：《临床外科杂志》2004年第S1期1-3,共3页Journal of Clinical Surgery

摘　　要：目的　研究不同温度下离体血管舒张和收缩功能的变化及其对苯肾上腺素 (phenyle phrine ,PE)和硝普钠 (sodiumnitroprusside ,SNP)的反应差异。 方法　记录在 3 7℃、2 8℃、2 5℃、2 1℃四组温度下大鼠离体肺动脉、主动脉血管条舒张、收缩功能曲线 ,同时测定四组不同温度下离体血管条对苯肾上腺素和硝普钠的反应曲线。结果　从 3 7℃逐渐降温至 2 1℃时 ,离体肺动脉血管条和主动脉血管条强烈舒张 ,而从 2 1℃逐渐升温至 3 7℃时 ,离体肺动脉血管条和主动脉血管条强烈收缩。同时 ,在四组不同温度下 ,离体肺动脉血管条和主动脉血管条对苯肾上腺素和硝普钠的反应有显著差异 ( P <0 .0 1)。结论　随着温度的升高 ,离体肺动脉血管条和主动脉血管条发生强烈收缩 ,而随着温度的降低 ,离体肺动脉血管条和主动脉血管条发生强烈舒张。同时 ,随着温度的升高 ,离体肺动脉血管条和主动脉血管条对苯肾上腺素的收缩反应和硝普钠的舒张反应明显增强 ;而随着温度的降低 ,离体肺动脉血管条和主动脉血管条对苯肾上腺素的收缩反应和硝普钠的舒张反应则明显减弱。Objective The purpose of this study is to observe how the temperature affect vasculars vasodilation and vasoconstriction in vitro,and the function change of vasculars at different temperatures in vitro.Methods At different temperatures:37℃、28℃、25℃、21℃,record rat pulmonary artery and aortic artery in vitro change curves and reaction curves of the vasculars in vitro to phenylephrine and sodium nitroprusside.Results From 37℃ to 21℃ vasculars in vitro have intensely vasodilated.In contrast,vasculars in vitro have stongly vasoconstricted from 21℃ to 37℃.The reactions of vasculars in vitro to phenylephrine and sodium nitroprusside have been significant different(P<0.01).Conclusion With stepwise heating, vasculars in vitro have vasoconstricted, and with stepwise cooling,vasculars in vitro have vasodilated.Along temperature increasing,vasculars in vitro have reacted to phenylephine and sodium nitroprusside intensively,and vasculars in vitro have reacted to phenylephine and sodium nitroprusside weakly during temperature decreasing.

关 键 词：离体血管条 温度 苯肾上腺素 硝普钠 血管收缩 血管舒张 

分 类 号：R654.3[医药卫生—外科学]