Cardiac toxicity of resibufogenin: electrophysiological evidence  

脂布福吉宁的心脏毒性作用:电生理学证据(英文)

作　　者：解景田 Lucy DEY 吴吉安 Tasha K LOWELL 袁钧苏 

机构地区：[1]Tang Center for Herbal Medicine Research, The Department of Anesthesia and Critical Care and Committee on Clinical Pharmacology, The Prizker School of Medicine, The University of Chicago, Chicago, Illinois, USA

出　　处：《Acta Pharmacologica Sinica》2001年第4期3-11,共9页中国药理学报（英文版）

摘　　要：Resibufogenin (RBG) is a single compound isolated from Chansu, a traditional Chinese medicine obtained from the skin venom gland of the toad. Formulations of Chansu have been widely applied in China, Japan, and other Asian countries for a long time and are currently used as alternative medicines. However, there have been several reports about the toxicity of Chansu and its medical formulations in the United States recently. As digitalis, RBG possesses both pharmacologic and toxico-logic effects. According to our study results, RBG, one of major ingredient of Chansu, induced delayed afterde-polarization and triggered arrhythmias both in cardiac flber in vitro and in beating heart in vivo at the high concen-trations. The electrophysiologic toxic effects of RBG, the possible mechanism of toxicity, and trealment possi-bilities are discussed in the present review.脂布福吉宁是从传统中药蟾酥中分离的单一化合物。长期以来,蟾酥制品广泛应用于中国、日本及亚洲其他国家。但是,近来在美国出现一些有关蟾酥及其药物制剂引起中毒的报告。如洋地黄一样,脂布福吉宁也具有药理和毒理作用。根据我们的实验结果,高浓度脂布福吉宁,蟾酥的主要成分之一,可以引起离体心肌细胞和在体心脏的延时性后去极化及触发性心律失常。本文对引起毒性的可能机制及治疗心律失常的可能性也进行了讨论。

关 键 词：BUFANOLIDES DIGITALIS ELECTROPHYSIOLOGY ARRHYTHMIA Purkinje fibers 

分 类 号：R285[医药卫生—中药学]