Endoxin: a major factor regulating cardiovascular system  

内源性洋地黄因子:调节心血管系统的一个重要因子(英文)

作　　者：柯永胜[1] 

机构地区：[1]皖南医学院弋矶山医院心脏科,芜湖中国241001

出　　处：《Acta Pharmacologica Sinica》2001年第3期11-19,共9页中国药理学报（英文版）

基　　金：Project supported by the Education Committee Foundation of Anhui (№ 99j10219) and Health Special Foundation of Anhui, China.

摘　　要：Endoxin is a factor with a digitalis-like biological activity. It is a Na+ pump inhibitor and may be an endogenous medium of digitalis receptor. There are abnormal plasma levels of endoxin in some pathophysiologic states such as hypertension, acute myocardial infarction, arrhythmia, heart failure, etc. Some studies have demonstrated that the abnormal endoxin levels may be implicated in pathogenesis of these diseases or pathophysiologic process involved. Therefore, to clarify the effects of endoxin has much significance in understanding pathogenesis, prevention and treatment of hypertension and other cardiovascular diseases.内源性洋地黄因子是一种具有洋地黄样生物活性的因子,是钠泵抑制剂和洋地黄受体的内源性递质。在某些病理生理状态下如高血压、急性心肌梗死、心律失常、心力衰竭等,血浆内源性洋地黄因子水平发生异常变化。一些研究证明,内源性洋地黄因子的分泌异常参与这些疾病的发病机制和病理生理过程。纠正这种异常可以预防和治疗这些疾病。因此,阐明内源性洋地黄因子的作用对明确高血压等心血管疾病的发病机制和防治具有重要意义。

关 键 词：hypertension cardiomegaly  myocardial infarction pulmonary heart disease congestive heart failure diabetes mellitus ARRHYTHMIA 

分 类 号：R54[医药卫生—心血管疾病]