乙型肝炎PreS1抗原、HBV DNA、HBeAg的相关性分析及临床应用  

Analysis of the relationship of serum pre-S1 to HBV DNA and HbeAg in patients with hepatitis B viral infection

作　　者：徐瑗瑗[1] 吴晓玲[1] 

机构地区：[1]安徽省立医院感染病科,合肥市230001

出　　处：《实用肝脏病杂志》2009年第2期101-103,共3页Journal of Practical Hepatology

摘　　要：目的分析乙型肝炎患者血清乙型肝炎病毒PreS1抗原、HBV DNA和HBeAg的临床意义。方法采用双抗体夹心法检测前S1蛋白,采用荧光PCR法检测HBV DNA,采用ELISA法检测HBeAg。结果在1258例乙型肝炎患者中PreS1抗原阳性率为26.39%,HBV DNA阳性率为83.39%;在1049例血清HBV DNA阳性患者中,PreS1抗原阳性299例(23.94%),HBeAg阳性447例(42.61%);在PreS1抗原阳性患者中,HBV DNA阳性率为92.57%(299/332)。结论本组资料显示,PreS1抗原的检测无更多的临床意义。Objective To study the clinical significance of PreS1,HBV DNA and HBeAg in patients with HBV infection. Methods PreS1 and HBeAg were deteeed by ELISA,and HBV DNA by fluorescence quantitative polymerase clain reaction assay. Result Among 1258 serum specimens,the positive rate of preS1 was 26.39%,while HBV DNA was 83.39%（P〈0.01）. Meanwhile,the positive rates of preS1 and HBeAg in patients with serum HBV DNA positive were 23.94%（299/1049） and 42.61%（447/1049）,respectively. However,the HBV DNA positive rate in patients with preS1 positive were 92.57%（299/332）. Conclusion The detection of preS1 is no more significant in clinical practice.

关 键 词：乙型肝炎 PRES1抗原 HBV DNA HBEAG 

分 类 号：R512.62[医药卫生—内科学] R-332[医药卫生—临床医学]