慢性乙型肝炎和肝硬化患者肝组织环氧合酶-2表达与肝窦病变的关系  

Relationship between cyclooxygenase-2 expression and sinusoidal lesions in patients with chronic hepatitis B

作　　者：徐长江[1] 严家春[1] 马勇[1] 李瑞斌[1] 邵先安[1] 袁苏娜[1] 胡菁菁[1] 

机构地区：[1]解放军第123医院肝病中心,安徽省蚌埠市233015

出　　处：《实用肝脏病杂志》2009年第2期111-113,共3页Journal of Practical Hepatology

摘　　要：目的探讨慢性乙型肝炎(CHB)和肝硬化(LC)患者肝组织环氧合酶-2表达与肝窦及窦周隙病变的关系。方法采用免疫组化法检测了200例CHB患者肝活检组织环氧合酶-2的表达,并分析其表达变化与肝窦及窦周隙病变的关系。结果慢性乙型肝炎和肝硬化患者的肝窦病变有狭窄、阻塞、扩张、窦周隙淤血、肝窦毛细血管化等改变。体视学研究发现肝窦数目减少,总面积、总周长和平均直径增加,与正常人存在显著性差异(P<0.01),与CHB轻、中度患者比,也有显著性差异(P<0.01);电镜观察示肝窦内皮撕裂,基膜形成,肝窦内皮细胞出芽形成血管腔,星状细胞转化为肌成纤维细胞,COX-2表达强弱与肝窦和窦周隙病变程度呈平行关系。结论环氧合酶-2表达增强参与了CHB患者肝窦及窦周隙病变的发病过程。Objective To study the relationship between cyclooxygenase-2（COX-2） expression and liver sinusoidal lesions in patients with chronic hepatitis B. Methods We studies the liver biopsies from 200 patients with chronic hepatitis B（CHB） by immunohistochemonieal staining for COX-2 expression,and the hepatic sinusoidal and Diss＇s space lesions were examined. Results There were constriction,emphraxis,dilatation, Disse＇s space congestion and sinusoidal capillirization in the liver of patients with CHB. Stereological studies showed that hepatic sinusoidal numbers decreased （P〈0.01） and total area,total girth and mean diameter increased （P〈0.01） as compared with normal persons and CHB-mild and CHB-moderate patients;electron microscope exam showed the laceration in the endothelium of sinuses,formation of basal lamina,sinusoidal endothelium budding formation lumen of blood vessel and fat-storing cell converted to myofibroblast;the COX-2 expression was parallel to the sinusoidal lesions. Conclusion COX-2 expression plays a role in hepatic sinusoidal and Disse＇s space lesions in CHB patients.

关 键 词：慢性乙型肝炎 肝硬化 环氧合酶-2 肝窦 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]