Epidemiological investigation of Histoplasma capsulatum infection in China  

我国部分地区组织胞浆菌感染的流行病学调查(英文)

作　　者：赵蓓蕾[1] 夏锡荣[1] 印洁[1] 张希龙[1] 吴鄂生 施毅[1] 童茂荣[1] 孙圣华 桂希恩 赵中苏 阿依努尔 冯小燕 

机构地区：[1]南京军区南京总医院呼吸科,南京210002

出　　处：《Chinese Medical Journal》2001年第7期71-74,108-109,共6页中华医学杂志（英文版）

摘　　要：Objectives To provide reliable information concerning the presence or the absence of Histoplasma capsulatum (H. capsulatum) infection in China, and data concerning this respect.Methods Three hundred normal people and 435 hospitalized patients, who lived in Hunan and Jiangsu provinces, and the Xinjiang Autonomous Region, were tested with yeast-phase histoplasmin (ALK/Berkerley Biologicals Laboratories, USA) and human pure protein derivative of tuberculin (PPD) on the volar surface of the forearm. Any reaction to the antigens over 5.0?mm in diameter of induration at 48-72?hours was considered positive. Results A total of 138 subjects (18.8%) in 735 patients reacted to histoplasmin with 5.0-45.0 (9.1±4.3)?mm indurations. Significant differences of positive skin reaction rates in normal subjects were found in Hunan, Jiangsu and Xinjiang (8.9% vs 15.1% vs 2.1%). The overall positive rate of patients was 25.5%. Patients with tuberculosis [31.7% (78/246)] had a significantly higher positive skin reaction rate in comparison with those suffering from pneumonia [17.7% (11/62)], lung cancer [20.9% (9/43)], chronic obstructive pulmonary disease [17.3% (9/52)] and other diseases [12.5% (4/32)] (P<0.01). Of 562 cases, 292 cases (52.0%) reacted to PPD with indurations of 5-50 (13.7±4.9)mm in diameter, 63 cases (11.2%) reacted to both histoplasmin and PPD, while 38 cases (6.9%) reacted to histoplasmin but not to PPD.Conclusions The data suggest that there is H. capsulatum herd infection in China. The infection rate in Southeast China is higher than that in the Northwest, and the infection rate of patients with pulmonary tuberculosis is higher than that of normal persons and other pneumonopathy patients.目的　组织胞浆菌病是一种地方性真菌病。我国的部份地区自然条件适宜于组织胞浆菌生长与传播 ,但缺乏组织胞浆菌感染的流行病学资料。本研究的目的是调查我国部份地区组织胞浆菌感染的流行情况。方法　 30 0例正常人和 4 35例住院病人分别来源于湖南、江苏省和新疆维吾尔自治区。前臂皮内注射酵母相组织胞浆菌素 (HIS ,美国ALK/BerkeleyBiologicalsLaboratories生产 )和结核菌素纯蛋白衍化物 (PPD) ,4 8- 72h观察结果 ,最大红肿硬结直径≥ 5mm为阳性。结果　 138/735 (18 8% )受试者HIS皮试阳性 ,阳性反应直径为 5 0 - 4 5 0 (9 1± 4 3)mm。湖南、江苏和新疆三地正常人组HIS皮试阳性率有显著差异 ,分别为 8 9% ,15 1% ,和 2 1% (P <0 0 5 ,P <0 0 1)。病人组HIS总阳性率为 2 5 5 % ,明显高于相应地区正常人组 (P <0 0 1)。肺结核病人 [31 7% (78/ 2 4 6 ) ]阳性率高于肺炎 [17 7%(11/ 6 2 ) ],肺癌 [2 0 9% (9/ 4 3) ],慢性阻塞性肺疾病 [17 3% (9/ 5 2 ) ]和其他疾病 [12 5 % (4/ 32 ) ](P <0 0 1)。PPD总阳性率为 5 2 0 % (2 92 / 5 6 2 ) ,阳性反应直径为 5 0 - 5 0 0 (13 7± 4 9)mm。两种抗原皮试均阳性者 11 2 % ,均阴性者 4 2 9% ,HIS皮试阳性而PPD阴性者 6 8%。结论　我国?

关 键 词：Histoplasma capsulatum · histoplasmin · tuberculin · skin tests · epidemiology 

分 类 号：R181.8[医药卫生—流行病学]