Association of angiotensin Ⅱ type 1 receptor gene polymorphism with essential hypertension  

血管紧张素Ⅱ受体 1基因多态性与原发性高血压的相关性研究(英文)

作　　者：蒋珍妮[1] 赵文胜[2] 俞锋[1] 徐耕[1] 

机构地区：[1]浙江大学医学院附属第二医院心内科,杭州310009 [2]浙江大学医学院附属第一医院麻醉科,杭州310006

出　　处：《Chinese Medical Journal》2001年第12期17-19,101-102,共5页中华医学杂志（英文版）

摘　　要：Objective To determine whether the polymorphism A1166C in the angiotensin Ⅱ type 1 receptor (AT1R) gene is associated with essential hypertension Methods A casecontrol study was carried out using 125 hypertensive and 103 normotensive subjects The AC variant at position 1166 (A1166C) of the AT 1R gene was identified by polymerase chain reaction (PCR) and PCR/restriction fragment length polymorphism (PCR/RFLP) analysis The digestion products were separated on 2% agarose gels and visualized with ethidium bromide under ultraviolet ray Results The differences in C1166 allele frequency and in the AC genotype distribution of the AT 1R gene between the hypertensive and normotensive groups were statistically significant (C allele: 0.092 vs 0.034, χ2=6.1.86,P<0.05; AC genotype: 0.184 vs 0.068, χ2=6.654,P<0.05) Conclusion The AC genotype is associated with essential hypertension, and the C allele may be a marker for predisposition to hypertension in Chinese Han population目的　本研究旨在观察中国汉族人血管紧张素Ⅱ受体 1基因多态性与原发性高血压的关系。方法　应用聚合酶链反应 限制性内切酶片段长度多态 (PCR RFLP)与电泳分型的方法检测 12 5例原发性高血压患者和 10 3例正常者AT1R基因 116 6位 (A116 6C)的多态性分布。结果　原发性高血压患者AT1R基因AC型频率比正常对照组高 (0 184vs 0 0 6 8,χ2 =6 6 5 4 ,P <0 0 5 ) ,C116 6等位基因频率原发性高血压组高于正常对照组 (0 0 92vs 0 0 34,χ2 =6 186 ,P <0 0 5 )。结论　在中国汉族人群中 ,AC基因型与原发性高血压有关 ,C等位基因可能是高血压的易感基因。

关 键 词：essential  hypertension  ·  angiotensin Ⅱ  ·  receptor    ·   gene  polymorphism 

分 类 号：R544.1[医药卫生—心血管疾病]