The relationship between cartilage end-plate calcification and disc degeneration: an experimental study  

作　　者：彭宝淦[1] 侯树勋[1] 施杞[2] 贾连顺[3] 

机构地区：[1]解放军304医院骨科,北京100037 [2]上海中医药大学骨伤所,上海200032 [3]第二军医大学长征医院骨科,上海200003

出　　处：《Chinese Medical Journal》2001年第3期84-88,110,共6页中华医学杂志（英文版）

摘　　要：Objective To study the relationship between cartilage end plate calcification and intervertebral disc degeneration Methods An experimental model of cervical disc degeneration in rabbits was established by resection of the cervical supraspinous and interspinous ligaments and detachment of the posterior paravertebral muscles from the cervical vertebrae Mechanical instability in the cervical spine elicited by this surgical intervention accelerated the process of intervertebral disc degeneration The extent of intervertebral disc degeneration was graded in morphologically, and the thicknesses of the calcified layer and the uncalcified layer of the cartilage end plate were measured in each degenerated cervical disc Results In less severely degenerative cervical discs, the morphology of the cartilage end plate showed nearly normal construction, and the tidemark was clear In severely degenerative discs, the matrix and cells showed fibrosis, the tidemark advanced, and the calcified cartilage thickened There exists a positive correlation between the thickness of the calcified layer of the cartilage end plate and the degree of cervical disc degeneration Conclusion The calcification of the cartilage end plate is the key factor that initiates and promotes cervical disc degeneration目的　研究椎体软骨终板钙化在椎间盘退变过程中的作用。方法　 2 0只新西兰兔随机分为造模与对照组 2组 ,每组再分 3个月和 8个月 2个观察亚组。切除造模组动物颈棘上、棘间韧带及分离颈椎后旁两侧肌肉 ,造成颈椎力学上的失衡而诱导兔颈椎间盘退行性改变。在术后 3个月和 8个月时分别处死动物 ,取颈椎间盘组织 ,行病理学检查在形态学上评定颈椎间盘退变程度 ,测定不同退变程度椎间盘软骨终板钙化层厚度。结果　退变程度较轻或基本正常的颈椎间盘 ,软骨终板结构良好 ,潮标清晰 ;退变程度较重的颈椎间盘 ,软骨终板发生明显纤维化 ,潮标前移 ,钙化软骨和软骨下骨板增厚。软骨终板钙化层厚度与椎间盘退变程度呈非常明显的相关性。

关 键 词：intervertebral disc  ·  degeneration   ·  cartilage end  plate  ·  calcification 

分 类 号：R68[医药卫生—骨科学]