Molecular regulation of development and differentiation in Streptomyces  

作　　者：NIELiping TANHuarong 

机构地区：[1]Institute,Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China,of Microbiology, Chinese Academy of Sciences, Beijing 100080, China

出　　处：《Chinese Science Bulletin》2001年第3期177-178,共2页

基　　金：This work was supported by the National Natural Science Foundation of China (Grant No. 39830010); the National Outstanding Youth Foundation of China (Grant No. 39925002);and the State Key Laboratory of Microbial Resources of China.

摘　　要：Development and differentiation is an important and leading research field in modern biology. Streptomyces has a complicated life cycle of morphological differentiation including the spore germination, aerial mycelium and spore formation. Each developmental stage has a distinguished morphological feature which greatly facilitates the identification of developmental mutants, the complementary cloning and the spatial and temporal expression of the genes involved in differentiation. This characteristic of Streptomyces is comparatively superior to other pro-karyotic bacteria such as Escherichia coli, Bacillus sub-tilis and Myxococcus xanthus. Moreover, Streptomyces also possesses a complicated physiological differentiation in which it produces a wide variety of secondary metabolites (more than half of the 12 000 or so known antibiotics), including many important antibiotics used in medi-

关 键 词：GENE Molecular regulation of development and differentiation in Streptomyces 

分 类 号：Q75[生物学—分子生物学]