Screening cervical lesions with Fourier transform infrared spectroscopy  

作　　者：GAO Tiyu LI Jun CI Yunxiang DONG Jianqiang KAN Xiu QUO Zhenquan 

机构地区：[1]Department of Chemistry,Peking University,Beijing 100871,China [2]Gansu Chinese Traditional Medical College,Lanzhou 730000,China [3]Department of Pathology,Beijing Medical University,Beijing 100044,China [4]Department of Biology,Peking University,Beijing 100871,China

出　　处：《Chinese Science Bulletin》2001年第3期213-216,共4页

基　　金：This work was supported by the National Natural Science Foundation of China (Grant No. 39730160);and also by China Postdoctoral Science Foundation.

摘　　要：The screening results were reported based on the Fourier transform infrared spectroscopy (FTIR) analysis of the samples of exfoliated cervical cells from 354 women. Their spectra can be sorted into two types based on the emerging or not of the absorption bands near 970 cm-1 and 1170 cnT1: Tl (83.1%) type without emerging, and T2 (16.9%) type with obviously emerging. All of the samples assigned to Tl were cytologicaily diagnosed as normal or within normal limits (Pap I). 28.9% and 71.1% of samples exhibiting T2 profile, were cytologicaily evaluated as Pap I and abnormal respectively. 3 women in the abnormal group were diagnosed as to have cervical cells with changes associated with high grade of inflammation, cervical scar and cervical erosion. Furthermore, based on the progressive change of the relative intensities of the absorption bands, both T1 and T2 profiles can be categorized into 6 subtypes. The observed heterogeneous spectra and the progressive changes in the absorption frequencies and theThe screening results were reported based on the Fourier transform infrared spectroscopy (FTIR) analysis of the samples of exfoliated cervical cells from 354 women. Their spectra can be sorted into two types based on the emerging or not of the absorption bands near 970 cm?1 and 1 170 cm?1: T1 (83.1%) type without emerging, and T2 (16.9%) type with obviously emerging. All of the samples assigned to T1 were cytologically diagnosed as normal or within normal limits (Pap I). 28.9% and 71.1% of samples exhibiting T2 profile, were cytologically evaluated as Pap I and abnormal respectively. 3 women in the abnormal group were diagnosed as to have cervical cells with changes associated with high grade of inflammation, cervical scar and cervical erosion. Furthermore, based on the progressive change of the relative intensities of the absorption bands, both T1 and T2 profiles can be categorized into 6 subtypes. The observed heterogeneous spectra and the progressive changes in the absorption frequencies and the relative intensities exhibit features suggestive of the progressive process of cervical lesion. The FTIR method has the potential to complement the cytological smear for large-volume screening of cervical lesions.

关 键 词：infrared SPECTRAL FEATURE EXFOLIATED CERVICAL cells SCREENING of CERVICAL lesions. 

分 类 号：R446.8[医药卫生—诊断学]