Photophysics,photochemistry and photobiology of hypocrel-lin photosensitizers  

作　　者：Lijin Jiang Yuying He 

机构地区：[1]Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100080, Peoples R China

出　　处：《Chinese Science Bulletin》2001年第1期6-16,共11页

摘　　要：Hypocrellins are novel photosensitizers from China, which are demonstrated to have significant anti-tumor and anti-virus activity and to be potential photo-dynamic therapy (PDT) agents. As compared with hemato-porphyrin, the only approved photosensitizer, hypocrellins have several advantages, such as easy preparation and easy purification, high triplet quantum yield, high singlet-oxygen quantum yield, high phototoxicity but low dark toxicity, and rapid clearance from normal issues. This article reviews briefly the photophysics, photochemistry and photobiology of hypocrellins on the basis of the domestic and international research results.Hypocrellins are novel photosensitizers from China, which are demonstrated to have significant antitumor and anti-virus activity and to be potential photodynamic therapy (PDT) agents. As compared with hematoporphyrin, the only approved photosensitizer, hypocrellins have several advantages, such as easy preparation and easy purification, high triplet quantum yield, high singlet-oxygen quantum yield, high phototoxicity but low dark toxicity, and rapid clearance from normal issues. This article reviews briefly the photophysics, photochemistry and photobiology of hypocrellins on the basis of the domestic and international research results.

关 键 词：hypocrellins PHOTOPHYSICS PHOTOCHEMISTRY photobio-logy photodynamic therapy (PDT). 

分 类 号：O644[理学—物理化学]