Studies on the Interactions between Potassium oxalato-oxodiperoxovanadate and Histidine by NMR and MS  

作　　者：Jian Liang YE Xing Wang ZHOU Zhong CHEN Zhi Wei CHEN Pei Qiang HUANG 

机构地区：[1]Department of Chemistry,Xiamen University,Xiamen 361005 [2]Department of Biology,Xiamen University,Xiamen 361005

出　　处：《Chinese Chemical Letters》2001年第11期987-988,共2页中国化学快报（英文版）

摘　　要：Multi-nuclear NMR and ESI-MS have been applied to study the interactions between oxalato-oxodiperoxovanadate and histidine in neutral solution. Coordination between the complex and histidine was monitored by V-51 NMR. A pair of new isomers produced via vanadium atom binding separately to N1 and N3 of the imidazole ring of histidine was characterized by several spectroscopic methods. Experimental results show that the structure activity relationship of peroxovanadium complexes bearing organic ligands may be related to the specific recognition between peroxovanadium and histidine residue of tyrosine phosphatase.Multi-nuclear NMR and ESI-MS have been applied to study the interactions between oxalato-oxodiperoxovanadate and histidine in neutral solution. Coordination between the complex and histidine was monitored by V-51 NMR. A pair of new isomers produced via vanadium atom binding separately to N1 and N3 of the imidazole ring of histidine was characterized by several spectroscopic methods. Experimental results show that the structure activity relationship of peroxovanadium complexes bearing organic ligands may be related to the specific recognition between peroxovanadium and histidine residue of tyrosine phosphatase.

关 键 词：oxalato-oxodiperoxovanadate HISTIDINE peroxovanadium NMR ESI-MS 

分 类 号：O657.63[理学—分析化学]