Progress in study of structure-function relationship and protein engineering of plasminogen activators  

作　　者：Fuxiang Zhu Fuchu He 

机构地区：[1]Beijing Inst Radiat Med, Beijing 100850, Peoples R China

出　　处：《Chinese Science Bulletin》1999年第4期289-294,共6页

摘　　要：Thrombolytic agents play an important role in the treatment of thrombus diseases. In clinic,traditional thrombolytic agents always resulted in the side effect of systemic thrombolysis because of the shortcomings, such as short half-life, poor specificity of thrombus. Recently, with the development of knowledge of the relationship between their structure and function, a series of new thrombolytic agents were constructed by means of molecular biological techniques. Developing new types of thrombolytic agents is of great significance for more effective treatment of cardiovascular diseases. The latest knowledge of the structure-function relationship of t-PA and u-PA and the progress in development of new thrombolytic agents are reviewed.Thrombolytic agents play an important role in the treatment of thrombus diseases. In clinic, traditional thrombolytic agents always resulted in the side effect of systemic thrombolysis because of the shortcomings, such as short half-life, poor specificity of thrombus. Recently, with the development of knowledge of the relationship between their structure and function, a series of new thrombolytic agents were constructed by means of molecular biological techniques. Developing new types of thrombolytic agents is of great significance for more effective treatment of cardiovascular diseases. The latest knowledge of the structure-function relationship of t-PA and u-PA and the progress in development of new thrombolytic agents are reviewed.

关 键 词：THROMBOLYTIC AGENTS T-PA U-PA variants. 

分 类 号：Q55[生物学—生物化学]