Interleukin-2 mediates the peripheral analgesia of interferon alpha  

作　　者：Li Li Qiwei Zhai Wei Tang Tong Wu Zhongcheng Zheng Xinyuan Liu 

机构地区：[1]Chinese Acad Sci, Shanghai Inst Biochem, Shanghai 200031, Peoples R China

出　　处：《Chinese Science Bulletin》1999年第3期243-246,共4页

摘　　要：Interferon-α (IFN-α) and interleukin-2 (IL-2) are crucial cytokines in immune system. They also play an important role in nerve system. It has been reported that IL-2 can induce the central analgesia. It is demonstrated that IFN-α also can induce the peripheral analgesia, which can be blocked by naloxone as IL-2. Furthermore, the analgesic effect of IFN-α is reversible by monoclonal anti-IL-2 antibody. In vitro experiments show that IFN-α significantly increases the production of IL-2 in a dose dependent manner. These data suggest that IL-2 mediates the peripheral analgesia of IFN-α.Interferonα (IFNα) and interleukin-2 (IL-2) are crucial cytokines in immune system. They also play an important role in nerve system. It has been reported that IL-2 can induce the central analgesia. It is demonstrated that IFNα also can induce the peripheral analgesia, which can be blocked by naloxone as IL-2. Furthermore, the analgesic effect of IFN-α is reversible by monoclonal anti-IL-2 antibody.In vitro experiments show that IFN-α significantly increases the production of IL-2 in a dose dependent manner. These data suggest that IL-2 mediates the peripheral analgesia of IFN-α.

关 键 词：IFN-Α IL-2 analgesia. 

分 类 号：R392[医药卫生—免疫学]