乙型肝炎病毒指标在不同年龄患者中的变化  

THE POSITIVE INCIDENCE OF HEPATITIS B VIRUS MARKERS IN DIFFERENT AGE OF CHINESE PERSONS.

作　　者：孙焱[1] 王豪[1] 张励 陶其敏[1] 冯百芳[1] 

机构地区：[1]北京医科大学人民医院肝病研究所,北京市100034

出　　处：《实用肝脏病杂志》1999年第4期198-201,共4页Journal of Practical Hepatology

摘　　要：目的 为了了解目前不同年龄组人群的乙肝病毒标志携带情况,更好地制定今后防治的方向。方法采用酶联免疫法对36819例就诊者进行人群的乙型肝炎两对病毒标志测定,并将携带乙型肝炎病毒标记阳性者按单项HBsAg阳性,单项抗-HBs阳性、HBsAg+HBeAg阳性、HBsAg+抗-HBe阳性,分为四组,并以十岁为一年龄段共分六段。结果 (1)共检出乙型肝炎病毒标记阳性者7439例,占受检者20.2％(7439/36819),其中单项HBsAg阳性2300例,单项抗-HBs阳性2293例,HBsAg+HBeAg阳性1099例,HBsAg+抗-HBe阳性1747例,全部病例男女之比1.071:1,携带乙型肝炎病毒标记男女之比1.496:1。(2)单项HBsAg阳性组男女之比1.78:1,HBsAg感染率随年龄的增长,男性患者无明显变化,女性患者60岁以后略有增加。单项抗-HBs阳性男女之比0.9:1,女性多于男性,阳性率的变化是平稳的,与年龄关系不大,HBsAg+HBeAg阳性组病人男性明显多于女性(2.90:1),阳性率随年龄增长而下降,但男性女性在21～40岁年龄段中男67.2％(594/817),女68.1％(192/282)。HBsAg+抗-HBe阳性组,该组男女之比1.71:1,随年龄的增长而升高,男性女性均在21～50岁年龄段中为阳性结果密集区,男性67.7％(745/100),女性76.5％(495/647)。结论Objective To investigate the incidence of HBV markers in Chinese persons in different ages who had carried HBV markers. Methods 36819 sera were tested for HBV markers by ELISA. These persons with HBV markers positive were divided into four groups: 1. HBsAg positive;2. Anti-HBs positive;3. HBsAg + HBeAg positive; 4. HBsAg + anti-HBe positive,and then they were also divided into 6 age sections by every ten years. Results 1.To- tal 7439 out of 36819 sera were positive for HBsAg or anti-HBs,and the ratio of male/female was 1.496:1 ;2. In the HBsAg positive alone group,the ratio of M/F was 1. 78:1. The incidence of HBsAg did not increase with aging in men but slightly increase in women when aged over 70 yrs. The incidence of anti-HBs in female was slightly higher than that in male. The incidence of HBeAg was much higher in male than that in female,and it decreased with aging. The positive rate of anti-HBc increased with aging in male and also in female. Conclusion The incidence of HBV markers today in male is higher than that in female. This result is consistent with that in 1970s. The incidence of anti-HBs in female is higher than that in male, and it is assumed that the immunological capability against HBV infection in female is stronger than that in male. HBeAg positive is commonly seen in the age group of 21-40 in male and female, and the treatment should be focused on this age section.

关 键 词：HBSAG 抗-HBS HBEAG 抗-HBE 

分 类 号：R512.62[医药卫生—内科学]