乌鲁木齐地区部分高危人群庚型肝炎病毒感染状况的研究  

PREVALENCE OF GBV-C/HGV IN INDIVIDUALS AT HIGH RISK OF INFECTION IN URUMQI REGION

作　　者：包永星[1] 孙蕙蓉[1] 牛海蛟 杜绍财[3] 李刚 包永军 

机构地区：[1]新疆医学院第一附属医院传染科,乌鲁木齐市830000 [2]新疆乌鲁木齐中心血站 [3]北京医科大学肝病研究所

出　　处：《实用肝脏病杂志》1999年第2期78-79,共2页Journal of Practical Hepatology

摘　　要：目的 了解新疆乌鲁木齐地区部分高危人群中庚型肝炎病毒的感染状况。方法 首先运用酶标法(ELISA)检测不同人群中庚型肝炎病毒抗体(抗-HGV),然后对抗-HGV阳性血清运用逆转录聚合酶链反应(RT-PCR)检测HGV RNA。结果 在各类高危人群中,抗-HGV阳性率分别是:手术受血者为35.59％(21/59),静脉吸毒者为38％(19/50),非甲～戊型肝炎病人为18％(9/50);均显著高于对照人群(2％,1/50,P<0.05);职业供血员抗-HGV阳性率也较高(13.79％,8/58),但与对照人群无显著性差异(P>0.05);58份抗-HGV阳性血清有18份血清HGV RNA阳性,其中手术受血者血清1份,静脉吸毒者血清12份,职业供血员血清2份,非甲～戊型肝炎病人血清3份。结论 (1)本研究首次在乌鲁木齐地区部分高危人群中证实有较高的庚型肝炎病毒感染率;(2)再次证实该病毒主要通过注射、输血途径传播。ELISA method was used for detection of serum anti-HGV and serum HGV RNA was tested by a reverse transcription nested polymerase chain reaction (RT-PCR) in anti-HGV positive sera. The positive rates of anti-HGV were 35. 59% (21/59) in group of blood-receivers, 38% (19/50) in group of intravenous drug-abusers and 18%(9/50)in group of non A-E hepatitis patients. The positive rate of anti-HGV among the professional blood-donors was also high( 13. 79% ,8/58). There were 18 serum samples positive for HGV RNA among 58 serum samples with anti-HGV( + ). The study for the first time reports the HGV infection in persons at high risk of blood-transmitted infection in Urumqi region.

关 键 词：庚型肝炎病毒 抗-HGV HGV RNA 

分 类 号：R512.6[医药卫生—内科学]