过继免疫疗法对子宫内膜异位症模型鼠免疫功能的影响  

Effect of adoptive immunotherapy on immune disturbances of EMT rats

作　　者：李淑萍[1] 萧美如 李同玺[3] 陆伯刚[4] 

机构地区：[1]武警医学院中医学教研室,天津300162 [2]天津医科大学第二附属医院妇科,天津300162 [3]天津中医学院第二附属医院病理科,天津300162 [4]天津医科大学免疫学教研室,天津300162

出　　处：《武警后勤学院学报（医学版）》1999年第3期133-135,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：目的：探讨过继免疫疗法对子宫内膜异位症的疗效及免疫功能的影响。方法：38只SD大鼠随机分为空白对照、模型对照、LAK细胞注射、LHRH－a注射四组。观察异位病灶变化，并分别测定各组大鼠腹腔液中自然杀伤细胞（NK细胞）活性及血清中白细胞介素－6（IL－6）、子宫内膜抗体（EMAb）的水平。结果：LAK细胞治疗组异位内膜萎缩，NK细胞活性提高，IL－6水平与子宫内膜抗体含量下降，各项指标与模型组均有显著差异。结论：LAK细胞能调整子宫内膜异位症紊乱的免疫机制，提示过继免疫疗法对子宫内膜异位症具有治疗作用。Objective: To investigate the changes of immunobiology of endometriosis (EMT) rats after adoptive immunotherapy (AIT). Methods: 38 SD rats were divided into four groups as thenormal group, the EMT model group, the lymphokine activated killer (LAK) cells group, the LHRH-a group. The natural killer(NK) cells activity in peritioneal fluid, interleukin-6 (IL-6) ac-tivity, and endometrium antibody (EMAb) content in serum were measured. Pathological changes of endometriosis were observed. Results: LAK cells group improved significantly NK cells activity, and reduced IL-6 activity and the content of EMAb in serum. Conclusion: LAK cells could rectify the immune disturbances of EMT. It implied that AIT is a potential target for treatment in EMT.

关 键 词：子宫内膜异位症 LAK细胞 过继免疫疗法 

分 类 号：R711.71[医药卫生—妇产科学]