脑缺血再灌流诱导的巨噬细胞增加的组织化学研究  

A HISTOCHEMICAL STUDY OF INCREASED OF MACROPHAGES INDUCED BY CEREBRAL ISCHEMIA AND REPERFUSION IN RAT BRAIN

作　　者：刘勇[1] 雷万龙[1] 赵根然[1] 凌凤东[1] 

机构地区：[1]西安医科大学神经生物学研究中心

出　　处：《中国组织化学与细胞化学杂志》1999年第1期61-63,共3页Chinese Journal of Histochemistry and Cytochemistry

基　　金：陕西省自然科学项目基金

摘　　要：用组织化学方法显示非特异性酯酶，观察了大鼠脑缺血再灌流脑组织巨噬细胞数量的变化。结果显示，大鼠脑缺血１ｈ再灌流２ｈ巨噬细胞数量明显高于正常对照组（Ｐ＜０．０５），再灌流１６ｈ，巨噬细胞数量最多。缺血侧皮质区与基底节区比较，后者巨噬细胞计数明显高于前者（Ｐ＜０．０５）。结果提示。Using histochemistry of nonspecific esterase method the change of macrophage number was observed in brain of rat after cerebral ischemia and reperfusion. The results showed that at 1h of ischemia followed by 2h of reperfusion, the number of macrophages was larger than that in the normal control group (P<0 05), at 16h of reperfusion, the count of macrophages reached the highest. The cells were more numerous in the basal ganglion area than in the cortex (P<0 05). The results suggested that the ischemia and reperfusion in rat brain might be related with the increase of macrophages.

关 键 词：巨噬细胞 脑缺血再灌流 组织化学 

分 类 号：R329-34[医药卫生—人体解剖和组织胚胎学]