大鼠三叉神经尾侧亚核内SPR阳性神经元与初级传入和下行投射纤维之间的突触联系  

SYNAPTIC CONNECTIONS BETWEEN SPR POSITIVE NEURONS AND PRIMARY AFFERENT AND DESCENDING PROJECTION TERMINALS IN THE CAUTAL TRIGEMINAL SUBNUCLEUS

作　　者：庄志业[1,2] 刘大庸[1,2] 李云庆[1,2] 

机构地区：[1]第一军医大学解剖学教研室 [2]第四军医大学解剖学教研室

出　　处：《中国组织化学与细胞化学杂志》1999年第2期2-7,共6页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：用追踪和免疫电镜技术研究三叉神经尾侧亚核（Ｖｃ）内Ｐ物质受体（ＳＰＲ）阳性神经元与初级传入和下行投射之间的突触联系。光镜观察发现，在Ｖｃ浅层，ＳＰＲ阳性神经元的分布与ＲＭｇ下行投射终末的分布有重叠。电镜观察发现，三叉初级传入终末和ＳＰＲ阳性神经元树突形成非对称性轴树突触；ＲＭｇ下行投射终末与ＳＰＲ阳性神经元树突也形成非对称性轴树突触，提示ＲＭｇ下行投射纤维可能通过直接作用于丘脑投射神经元对三叉初级传入的伤害性信息进行调控。Synaptic connections between substance P receptor (SPR) positive neurons and primary affterent and descending projection terminals in the caual trigeminal subnucleus (Vc) were studied by using tracing methods and immunoelectromicroscope techniqes. Light microscopic observations showed that the distributions of SPR positive neurons and PHA L anterogradely labeled terminals originated from nucleus raphe magnus (RMg) overlapped with each other in the superficial laminae of the Vc. Electron microscopic observations revealed that both degeneratedly primary trigeminal afferent terminals and descending projection terminals originated from RMg formed asymmetrical axodendritic synapses with SPR positive neurons. These results suggest that RMg neurons may modulate primary afferent nociceptive information via direct control on thalamic projection neurons in the superficial laminae of V c.

关 键 词：追踪 免疫电镜 P物质受体 三叉神经尾侧亚核 大鼠 

分 类 号：R322-33[医药卫生—人体解剖和组织胚胎学]