急性移植物抗宿主病发生过程中供者T细胞迁移和归巢的机制  

Mechanism of Donor T cell Migration and Homing in the Pathophysiology of Acute Graft-versus-Host Disease——Review

作　　者：孙丽霞[1] 任汉云[1] 

机构地区：[1]北京大学第一医院血液科,北京100034

出　　处：《中国实验血液学杂志》2009年第2期519-522,共4页Journal of Experimental Hematology

摘　　要：供者T细胞向次级淋巴器官的迁移以及活化的供者T细胞向急性移植物抗宿主病(aGVHD)靶器官的迁移归巢是aGVHD发生的关键环节之一,深入认识供者T细胞的归巢机制对aGVHD的防治具有重要意义。本文就供者T细胞向次级淋巴器官的迁移,活化的供者T细胞向aGVHD靶器官的归巢,供者调节性T细胞向aGVHD靶器官的归巢和aGVHD过程中T细胞迁移归巢机制及其研究前景等进行了综述。Migration of donor T cells to the host second lymphoid organs and homing of activated donor T cells into the target tissues play crucial role in the pathophysiology of acute graft-versus-host disease （aGHVD）. More deep understanding of the mechanisms for donor T cell migration and homing reveals an important significance in preventing the initiation of aGVHD. In this review, the migration of donor T cells to host second lymphoid organs, homing of donor activated T cells into the target organs, homing of regulating T cells into target organs, the mechanisms of T cell migration and homing in process of aGVHD and its study prospects were summaried.

关 键 词：急性移植物抗宿主病 T细胞 供者T细胞迁移 供者T细胞归巢 

分 类 号：R457.7[医药卫生—治疗学]