肝素对组织型纤溶酶原激活剂的作用  

The effects of heparin on tissue-type plasminogen activator

作　　者：吴本传[1] 陈昭烈[1] 刘红[1] 李世崇[1] 林福玉[1] 

机构地区：[1]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》1999年第3期195-197,共3页Letters in Biotechnology

摘　　要：重组组织型纤溶酶原激活剂 ( rt PA)经肝素处理后与未经处理的 rt PA比较 ,结果显示 ,rt PA在体外的溶纤活性提高 5 0 %～ 90 % ,在兔体内的半衰期延长 1 min,同时也提高了 rtThe aim of this study was to evaluate the effects of heparin on recombinant tissue type plasminogen activator(rtPA) .After the rtPA was treated with heparin, the heparin rtPA compared with the native rtPA shows that the fibrinogenolytic activity was enhanced about 50%～90% in vitro, the half life was prolonged about 1 min in animal model of rabbit, and the ability of resist heat was also higher.

关 键 词：肝素 重组组织型纤溶酶原激活剂 半衰期 

分 类 号：R965[医药卫生—药理学]